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  • Book
    Richard R. Heuser, Markus Schlaich, Horst Sievert, editors.
    Summary: This book examines renal pathophysiology and the rationale for renal denervation (RDN), a minimally invasive, endovascular catheter based procedure using radiofrequency ablation for the treatment of resistant hypertension, a leading cause of morbidity and mortality in western civilization. In addition, the possible long term benefits and risks of this new therapy are discussed together with a description of the myriad of currently available devices and approaches involved in the evolution of this treatment. Lastly, the book focuses on the cost effectiveness of renal denervation and future directions for other possible benefits. Written by world renowned leaders in the field, Renal Denervation will be of immediate use to cardiologists, nephrologists and urologists as well as allied health professionals, device companies and anyone working in this field.
    Digital Access Springer 2015
  • Article
    Glazer RI, Peale AL.
    Cancer Lett. 1979 Apr;6(4-5):193-8.
    The adenosine analogs, 9-beta-D-xylofuranosyladenine (XA) and 3'-deoxyadenosine (cordycepin) were tested for their ability to interfer with S-adenosyl-L-methionine (SAM) formation in L1210 cells in vitro. XA inhibited the incorporation of [3H]methionine into SAM in a mixed-competitive manner, while cordycepin was not inhibitory. The adenosine deaminase inhibitor, 2-deoxy-coformycin produced a marked potentiation of the inhibitory effect of XA on Sam synthesis, but did not affect the inactivity of cordycepin. These results indicate that the inhibitory action of XA, but not cordycepin, on the methylation of nuclear RNA may be attributed to interference with the synthesis of SAM.
    Digital Access Access Options