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  • Book
    Andrew J. Krentz, Lutz Heinemann, Marcu Hompesch, editors.
    Summary: This book aims to aid the selection of the most appropriate techniques for use in early phase (1 and 2) clinical studies of new drugs for diabetes, obesity, and related cardiometabolic disease. Clinical research methods for assessing the pharmacokinetics and pharmacodynamics of new diabetes drugs, e.g. the euglycaemic clamp technique, have become well-established in proof-of-mechanism studies; however, selection of the best techniques is by no means straightforward. This book will aid the understanding of the need for new pharmacotherapies for type 1 diabetes, type 2 diabetes, and obesity and the molecular targets of drugs currently in development. Emerging technologies including the omics disciplines are considered together with practical and ethical issues of early phase clinical trials in subjects with cardiometabolic disorders. Translational Research Methods for Diabetes, Obesity and Cardiometabolic Drug Development will be of interest to biomedical scientists, pharmacologists, academics involved in metabolic research and clinicians practicing in these specialties.

    Contents:
    1. Review of physiology/pathophysiology
    2. Methods for assessing insulin action in humans
    3. Assessment of insulin secretion
    4. Measurement of ectopic fat in liver and muscle using magnetic resonance spectroscopy
    5. Isotopic tracers for the measurement of metabolic flux
    6. Measuring food intake in clinical drug development
    7. Measurement of energy expenditure
    8. Assessment of body composition
    9. Assessment of cardiovascular safety of new diabetes drugs.
    Digital Access Springer 2015
  • Article
    Bernard D.
    Can J Surg. 1979 May;22(3):278-82.
    The posterior (Kraske) approach to the surgical management of villous tumours of the rectum was used in 12 patients. One patient died in the postoperative period and in six others there were complications (wound infection in three, wound infection and rectal hemorrhage in one, wound dehiscence in one and cellulitis in one), but there was not a single fistula. This approach represents an easy and well-tolerated operation especially in older patients who are otherwise poor operative risks. The posterior approach is also excellent for excising lesions of the mid-rectum that may be too bulky for endoscopic removal and too proximal for their excision through the dilated anus. The procedure is not appropriate for malignant tumours and the benign nature of these tumours is best appreciated preoperatively by digital palpation; however, confirmation of their exact nature requires microscopic examination of the whole lesion.
    Digital Access Access Options