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  • Book
    Norbert Weiss, Alexandra Koschak, editors.
    Summary: Calcium ions represent Mother Nature's "ion-of-choice" for regulating fundamental physiological functions, as they initiate a new life at the time of fertilization and guide subsequent developmental and physiological functions of the human body. Calcium channels, which act as gated pathways for the movement of calcium ions across the membranes, play a central part in the initiation of calcium signals, and defects in calcium channel function have been found to result in a plethora of human diseases, referred to as the calcium channelopathies. Pathologies of Calcium Channels brings together leading international experts to discuss our current understanding of human diseases associated with the various calcium channels, from their molecular basis to potential future therapeutic targeting of calcium channels.

    Contents:
    Part I. Pathologies of Voltage-Gated Calcium Channels
    Part II. Pathologies of Transient Receptor Potential Channels
    Part III. Pathologies of Ligand-Gated Calcium Channels.
    Digital Access Springer 2014
  • Article
    Gliński W, Haftek M, Obałek S, Jabłońska S.
    Arch Immunol Ther Exp (Warsz). 1978;26(1-6):755-60.
    Patients with psoriasis were found to have less intensive experimental DNCB sensitization and decreased lymphocyte response to nonspecific mitogens, PHA, Con A, and PWM. E rosette formation was defective only in active psoriasis, in contrast to normal T and B cell counts. A reduction in DNCB hypersensitivity development and the percentage of E rosette forming lymphocytes were related to disease activity, but not to extention of skin lesions. The defect of E rosette function appeared to be transitional and completely disappeared in the remission. Abnormalities in CMI in psoriasis were found to be related at least partially to the existence in patients sera of a factor inhibiting normal T lymphocyte function. The study provides no evidence for the presence of primary CMI defect in psoriasis.
    Digital Access Access Options