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  • Book
    Mauro D'Amato, John D. Rioux, editors.
    Summary: Inflammatory bowel disease (IBD) affects 1% of people worldwide. This condition is partly inherited, and genetic research has made enormous progress during the last few years, providing important insight into disease pathogenesis. This book provides a concise but complete overview of existing knowledge, with particular focus on the molecular and genetic mechanisms at the basis of IBD. Invited experts, at the frontline of IBD research, introduce basic concepts in the pathophysiology of IBD and its two major forms Crohn?s disease and ulcerative colitis, provide a historical perspective and highlight latest discoveries of IBD genetic research, describe how this information has helped to unravel novel pathogenetic pathways, and formulate a vision for future investigations and their clinical application in IBD. State-of-the-art information contained in this book is an exceptional resource for all those in the biomedical field with a specific interest in IBD, including basic scientists, gastroenterologists, GI specialist doctors and research nurses, but also medical and biomedical students.

    Contents:
    Part I: The Foundation of IBD Genetics, Human and Animal Studies. A Primer on IBD: Phenotypes, Diagnosis, Treatment, and Clinical Challenges / Xinjun Cindy Zhu and Richard P. MacDermott
    Genetic Epidemiology of Inflammatory Bowel Disease, Early Twin and Family Studies / Jonas Halfvarson
    Insights from Recent Advances in Animal Models of Inflammatory Bowel Disease / Emiko Mizoguchi, Atsushi Mizoguchi and Atul K. Bhan
    Part II: The Genetic and Molecular Makeup of Inflammatory Bowel Disease. Complex Disease Genes and Their Discovery / Jeffrey C. Barrett and Mark J. Daly
    The Genetics of Crohn's Disease / Andre Franke and Miles Parkes
    Genetics of Ulcerative Colitis / Mauro D'Amato, Catherine Labbé and John D. Rioux
    Genetic Overlap Between Inflammatory Bowel Disease and Other Diseases / Charlie W. Lees and Alexandra Zhernakova
    Molecular Profiling of IBD Subtypes/Response to Therapy / Isabelle Cleynen and Séverine Vermeire
    Epigenetics of Inflammatory Bowel Disease / Robert Häsler, Stefan Schreiber and Stephan Beck
    Part III: Pathogenetic Pathways in Inflammatory Bowel Disease. Nod1 and Nod2 and the Immune Response to Bacteria / Maria Kaparakis-Liaskos, Dana J. Philpott
    The IL23-Th17 Axis in Intestinal Inflammation / Kevin J. Maloy
    Inflammatory Bowel Disease at the Intersection of Autophagy and Immunity: Insights from Human Genetics / Natalia B. Nedelsky, Petric Kuballa and Adam B. Castoreno
    The Epithelial Barrier / Stefan Koch, Asma Nusrat and Charles A. Parkos
    Host Interactions with Bacteria: From "Entente Cordiale" to "Casus Belli" / Nouara Lhocine and Philippe J. Sansonetti
    Cytokines in Inflammatory Bowel Disease / Matthias A. Engel and Markus F. Neurath
    Part IV: Concluding Remarks and Future Perspectives. Towards Personalized Therapy in Inflammatory Bowel Disease / Dermot P.B. McGovern.
    Digital Access Springer 2013
  • Article
    Manelfe C, Guiraud B, Espagno J, Rascol A.
    Rev Neurol (Paris). 1978 Aug-Sep;134(8-9):471-84.
    Metrizamide, a new water-soluble contrast medium with low toxicity, was used for cranial computed tomography (computerized cisternography) in 26 patients. When injected by lumbar puncture, the pericerebral cisterns (posterior fossa and sella turcica especially), can be visualized with much greater precision than with classical computed tomography. It also allows the normal and pathological circulation of the CSF to be studied. The authors report on 6 cases of tumours of the posterior fossa, 10 cases of pituitary tumours, 2 cases of "empty" sella, 2 cases of CSF rhinorrhoea, 2 cases of normal pressure hydrocephalus, and 2 cases of syringomyelia, studied by this method. The examination was normal in 3 cases. The authors stress the rapidity, reliability, and good tolerance of this new method.
    Digital Access Access Options