BookMauro D'Amato, John D. Rioux, editors.
Summary: Inflammatory bowel disease (IBD) affects 1% of people worldwide. This condition is partly inherited, and genetic research has made enormous progress during the last few years, providing important insight into disease pathogenesis. This book provides a concise but complete overview of existing knowledge, with particular focus on the molecular and genetic mechanisms at the basis of IBD. Invited experts, at the frontline of IBD research, introduce basic concepts in the pathophysiology of IBD and its two major forms Crohn?s disease and ulcerative colitis, provide a historical perspective and highlight latest discoveries of IBD genetic research, describe how this information has helped to unravel novel pathogenetic pathways, and formulate a vision for future investigations and their clinical application in IBD. State-of-the-art information contained in this book is an exceptional resource for all those in the biomedical field with a specific interest in IBD, including basic scientists, gastroenterologists, GI specialist doctors and research nurses, but also medical and biomedical students.
Contents:
Part I: The Foundation of IBD Genetics, Human and Animal Studies. A Primer on IBD: Phenotypes, Diagnosis, Treatment, and Clinical Challenges / Xinjun Cindy Zhu and Richard P. MacDermott
Genetic Epidemiology of Inflammatory Bowel Disease, Early Twin and Family Studies / Jonas Halfvarson
Insights from Recent Advances in Animal Models of Inflammatory Bowel Disease / Emiko Mizoguchi, Atsushi Mizoguchi and Atul K. Bhan
Part II: The Genetic and Molecular Makeup of Inflammatory Bowel Disease. Complex Disease Genes and Their Discovery / Jeffrey C. Barrett and Mark J. Daly
The Genetics of Crohn's Disease / Andre Franke and Miles Parkes
Genetics of Ulcerative Colitis / Mauro D'Amato, Catherine Labbé and John D. Rioux
Genetic Overlap Between Inflammatory Bowel Disease and Other Diseases / Charlie W. Lees and Alexandra Zhernakova
Molecular Profiling of IBD Subtypes/Response to Therapy / Isabelle Cleynen and Séverine Vermeire
Epigenetics of Inflammatory Bowel Disease / Robert Häsler, Stefan Schreiber and Stephan Beck
Part III: Pathogenetic Pathways in Inflammatory Bowel Disease. Nod1 and Nod2 and the Immune Response to Bacteria / Maria Kaparakis-Liaskos, Dana J. Philpott
The IL23-Th17 Axis in Intestinal Inflammation / Kevin J. Maloy
Inflammatory Bowel Disease at the Intersection of Autophagy and Immunity: Insights from Human Genetics / Natalia B. Nedelsky, Petric Kuballa and Adam B. Castoreno
The Epithelial Barrier / Stefan Koch, Asma Nusrat and Charles A. Parkos
Host Interactions with Bacteria: From "Entente Cordiale" to "Casus Belli" / Nouara Lhocine and Philippe J. Sansonetti
Cytokines in Inflammatory Bowel Disease / Matthias A. Engel and Markus F. Neurath
Part IV: Concluding Remarks and Future Perspectives. Towards Personalized Therapy in Inflammatory Bowel Disease / Dermot P.B. McGovern.