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  • Database
    Summary: Provides access to statistics and studies gathered by market researchers, trade organizations, scientific publications, and government sources on over 600 industries.
    Digital Access Database
  • Article
    Hayman RJ, Fong H, Van der Weyden MB.
    J Lab Clin Med. 1979 Mar;93(3):480-4.
    A rapid radiometric assay for the folate antagonist MTX, based on the inhibition of chicken liver dihydrofolate reductase activity, has been developed. In the system the inhibition by MTX of the reduction of tritiated FH2 is standardized and used to quantitate this antagonist in plasma of subjects receiving high-dose MTX therapy. The assay permits the detection of plasma MTX levels to 5 X 10(-9)M with a coefficient of variation of 15%. The predominating circulating folate, 5 methyltetrahydrofolate, or the rescue agent leucovorin (5 formyltetrahydrofolate) do not significantly interfere with the assay at concentrations attainable with current rescue programs. Analyses of multiple plasma samples with the present assay show close agreement with the competitive protein-binding assay.
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