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  • Book
    [edited by] James D. Cox, K. Kian Ang.
    Summary: Radiation Oncology: Rationale, Technique, Results, by James D. Cox, MD and K. Kian Ang, MD, PhD, provides you with authoritative guidance on the latest methods for using radiotherapy to treat patients with cancer. Progressing from fundamental principles through specific treatment strategies for the cancers of each organ system, it also addresses the effects of radiation on normal structures and the avoidance of complications. This 9th edition covers the most recent indications and techniques in the field, including new developments in proton therapy and intensity-modulated radiotherapy (IMRT). It also features, for the first time, full-color images throughout the text to match those that you see in practice, and uses new color-coded treatment plans to make targets, structures, and doses easier to read at a glance. Evidence from randomized clinical trials is included whenever possible to validate clinical recommendations. The state-of-the-art coverage inside this trusted resource equips you to target cancer as effectively as possible while minimizing harm to healthy tissue. Stands apart as the only book in the field to cover the conceptual framework for the use of radiotherapy by describing the most effective techniques for treatment planning and delivery and presenting the results of each type of therapy. Emphasizes clinical uses of radiation therapy, providing pertinent, easy-to-understand information on state-of-the-art treatments. Includes information useful for non-radiotherapists, making it "recommended reading" for other oncology specialists. Offers a practical, uniform chapter structure to expedite reference.

    Contents:
    Physical and biologic basis of radiation therapy
    Clinical radiation oncology physics
    Principles of combining radiation therapy and surgery
    Principles of combining radiation therapy and chemotherapy
    Principles of combining radiation therapy and molecular therapeutics
    The skin
    Advances in the treatment of head and neck cancer
    The salivary glands
    The nasal cavity and paranasal sinuses
    The nasopharynx
    The oropharynx
    The oral cavity
    The larynx hypopharynx
    The orbit
    The temporal bone, ear, and paraganglia
    The thyroid
    The breast
    The blood vessels and heart
    The lung, pleura, and thymus
    The esophagus
    The stomach and small intestine
    The pancreas
    The liver and biliary system
    The colon and rectum
    The anal region
    The urinary bladder
    The testicle
    The prostate
    The uterine cervix
    The endometrium
    The vulva and vagina
    The ovary
    The brain and spinal cord
    Leukemias and lymphomas
    The bone
    The soft tissue
    Childhood cancer
    Radiation therapy for bone marrow or stem cell transplantation
    Palliative care
    Proton therapy.
    Digital Access ScienceDirect 2010
  • Article
    Yorio T, Bentley PJ.
    J Endocrinol. 1978 Dec;79(3):283-90.
    Aldosterone, at a concentration of 10(-8)mol/1, increases the short-circuit current (scc, a measure of active sodium transport) across the skin of the frog (Rana pipiens). The other natural amphibian corticosteroid hormone, corticosterone, is about 100 times less potent. The structure-activity relationships of a number of corticosteroids were studied with respect to this response. An 11 beta-hydroxyl group was essential, whereas unsaturation at the C-1 to C-2 positions abolished activity. A 17-hydroxyl group did not enhance the response. Fluorination at the 9 alpha-position increased the affinity of the steroid for the receptor. Synthetic corticosteroids which have a high ratio of glucocorticoid : mineralocorticoid action can increase the scc and one of these, dexamethasone, was even more potent than aldosterone. A methyl group at C-16 appeared to be an important constituent for this response but it had to be in the alpha-position. The effects of both aldosterone and dexamethasone were inhibited by spironolactone. The results are discussed in relation to the nature of the response and to corticosteroid receptors in the skin of amphibians.
    Digital Access Access Options