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  • Book
    edited by Robert W. Schrier.
    Contents:
    The edematous patient : cardiac failure, cirrhosis, and nephrotic syndrome / Robert W. Schrier and David H. Ellison
    The patient with hyponatremia or hypernatremia / Robert W. Schrier and Tomas Berl
    The patient with hypokalemia or hyperkalemia / Jie Tang and Stuart L. Linas
    The patient with an acid-base disorder / William D. Kaehny
    The patient with disorders of serum calcium and phosphorus / Jeffrey G. Penfield and Robert F. Reilly
    The patient with kidney stones / Robert F. Reilly
    The patient with urinary tract infection / Jessica B. Kendrick, L. Barth Reller, and Marilyn E. Levi
    The patient with hematuria, proteinuria, or both, and abnormal findings on urinary microscopy / Godela Brosnahan
    The patient with glomerular disease or vasculitis / Sarah E. Panzer and Joshua M. Thurman
    The patient with acute kidney injury / Sarah Faubel and Charles L. Edelstein
    The patient with chronic kidney disease / Michel Chonchol and Jessica B. Kendrick
    The patient receiving chronic renal replacement with dialysis / Seth Ferguson and Isaac Teitelbaum
    The patient with a kidney transplant / James Cooper, Lawrence Chan, and Alexander Wiseman
    The patient with kidney disease and hypertension in pregnancy / Phyllis August, Diana I. Jalal, and Judy Blaine
    The patient with hypertension / Seth Ferguson, Charles R. Nolan, and Robert W. Schrier
    Practical guidelines for drug dosing in patients with impaired kidney function / Ali Olyaei and William Bennett.
    Digital Access Ovid 2015
    Print Access Request
    Location
    Version
    Call Number
    Items
    Books: General Collection (Downstairs)
    2015
    RC902 .M992 2015
    1
  • Article
    Grinstein S, Candia O, Erlij D.
    J Membr Biol. 1978;40 Spec No:261-80.
    An attempt to define the main categories of regulatory mechanisms of transepithelial sodium transport across tight epithelia is presented. In particular, evidence suggesting two types of mechanisms, changes in surface potential and the level of cell Ca, are described in greater detail. We have measured the effects of conditions that affect surface potential on the transepithelial sodium transport. Those conditions that increase the screening of negative charge and therefore depolarize the outer membrane are expected to have effects homologous to a depolarization caused by external current. Indeed, when the composition of the outside solution was modified by (i) increasing ionic strength, (ii) adding polyvalent cations (La+++, Co++, Ni++, Cd++), or (iii) lowering pH, an increase in active Na transport was detected. Moreover, the presence of small concentrations of polyvalent cations which screen surface charge, markedly dampens or even eliminates the effects of pH or ionic strength on Na transport. These findings provide additional support for the notion that a potential-sensitive component regulates Na movements across the apical membrane of the frog skin, and offer a framework to understand the effects of numerous cationic agents on transepithelial transport that hitherto remain unexplained. With respect to the role of intracellular Ca we have found that procedures that increase cell Ca, like removal of sodium in the basal solution or addition of ionophore A23187, reduce transepithelial Na transport. Moreover, conditions that block the increase in cell Ca prevent the inhibition of transport. These observations suggest that the level of intracellular Ca may determine the rate of transepithelial Na transport.
    Digital Access Access Options