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- BookLawrence D. Longo ; foreword by John R.G. Challis.Summary: During the mid- to late-twentieth century, study of the physiology of the developing fetus and newborn infant evolved rapidly to become a major discipline in the biomedical sciences. Initially of interest from a standpoint of function of the placenta and oxygenation of the fetus, the field advanced to explore both normal functional mechanisms as well as pathophysiologic aspects of their regulation. Examples include studying the role and regulation of circulatory vascular anatomic shunts in oxygenation, cardiac function, certain aspects of asphyxia in the fetus and newborn infant, the role of fetal breathing movements, cyclic electroencephalographic activity, and analysis of electronic monitoring of fetal heart rate variability and its significance. Included in this book are reminisces of several dozen individuals who played a vital role in these developments. Overall, this survey considers a number of aspects of the development of the science of fetal and neonatal physiology, and its role in the greatly improved care of pregnant women and their newborn infants.
Contents:
A Scientific Genealogy: The Development of Fetal-Neonatal Research
Oxford and the Development of Physiology, with Notes on the Nuffield Institute
Geoffrey S. Dawes: A Life in Science
Dawes and Fetal Asphyxia: The Primate Colony in Puerto Rico
Dawes, the Pulmonary Vasculature and his Foetal and Neonatal Physiology
Embryology and Early Developmental Physiology
Some Aspects of the Physiology of the Placenta
Governmental Support of Research in Fetal and Newborn Physiology
Fetal-Neonatal Growth and Metabolism
Epigenetics and the Fetal Origins of Adult Heath and Disease
Related Developments in Fetal and Neonatal Endocrinology
Further Developments in Fetal and Neonatal Physiology
Some Clinical Aspects of Developmental Physiology
Bioethical Issues in Research on the Fetus and Newborn Infant
Textbooks, Monographs and other Volumes on Fetal and Newborn Physiology
Dawes and Fetal Breathing in the 1970s, and Fetal Heart Rate Analysis in the 1980s and early 1990s
Dawes Contributions to Symposia and a Summing Up
Dawes as a Mentor: Reminisces of Former Graduate Students, Postdoctoral Fellows, and Associates
Early Years of the Society for Gynecologic Investigation, the Fetal and Neonatal.Digital Access Springer 2013 - ArticleWatanabe T, Kimoto M, Maruyama S, Kishimoto T, Yamamura Y.J Immunol. 1978 Nov;121(5):2113-7.Establishment of a mouse T hybrid cell line secreting suppressor factor(s) specific for the IgE antibody response is described. Fusion was made with polyethyleneglycol between AKR-derived T lymphoma cells (BW5147) and T cells from mice sensitized with DNP-Mycobacterium. Treatment of spleen cells with nondialyzable factor(s) in the culture supernatants of the T cell hybrid clone, 26-M10, showed a suppressive effect on IgE formation but not on IgG formation in adoptive transfer experiments. The suppressive effect was exerted through inactivation of normal or antigen-primed B cells responsible for IgE formation. It was also shown by direct cytotoxic test that the hybrid cells expressed H-2 and Thy-1 antigens derived from both parental cells on their surface. Karyotype analysis of the hybrid cells revealed that the number of chromosomes was less than the sum of the two parental cells' and the average was 50 (45 to 55). Although the 26-M10 hybrid cells lost the ability to secrete active suppressive factor(s) into culture medium 21 weeks after hybridization when the number of chromosomes in most of the cells was less than 41, recloning of the 26-M10 cells successfully recovered active suppressive clones.