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  • Book
    edited by Melanie A. Simpson, Paraskevi Heldin.
    Contents:
    Ch. 1. Emerging roles for hyaluronidase in cancer metastasis and therapy
    Ch. 2. Targeting hyaluronic acid family for cancer chemoprevention and therapy
    Ch. 3. Aberrant posttranscriptional processing of hyaluronan synthase 1 in malignant transformation and tumor progression
    Ch. 4. Hyaluronan synthases posttranslational regulation in cancer
    Ch.4. Hyaluronan synthases posttranslational regulation in cancer
    Ch. 5. Hyaluronan-coated extraellular vesicles, a novel link between hyaluronan and cancer
    Ch.6.Hyaluronan in the healthy and malignant hematopoietic microenvironment
    Ch. 7. Hyaluronan regulation of endothelial barrier function in cancer
    Ch. 8. HAS2 and CD44 in breast tumorigenesis
    Ch. 9. CD44 is a multidomain signaling platform that integrates extracellular matrix cues with growth factor and cytokine signals
    Ch. 10. Hyaluronan-CD44 interaction promotes oncogenic signaling, microRNA functions, chemoresistance, and radiation resistance in cancer stem cells leading to tumor progression
    Ch. 11. Advances and advantages of nanomedicine in the pharmacological targeting of hyaluronan-CD44 interactions and signaling in cancer
    Ch.12. Hyaluronan/RHAMM interactions in mesenchymal tumor pathogenesis: role of growth factors
    Ch. 13. CD147: regulator of hyaluronan signaling in invasiveness and chemoresistance
    Index.
    Digital Access ScienceDirect 2014
  • Article
    Garaci E, Ronchetti R, Del Gobbo V, Tramutoli G, Rinaldi-Garaci C, Imperato C.
    J Allergy Clin Immunol. 1978 Dec;62(6):357-62.
    Serum thymic factor (STF) activity was assayed in 26 young asthmatic patients and in 20 age-and sex-matched controls, in view of the increasing importance attributed to this thymic product in regulating several immune mechanisms. Determinations of total and specific IgE and of other immunoglobulins and skin tests were also performed. Decreased STF activity and high total and specific IgE concentrations were observed in the majority of asthmatic patients. In controls, STF activity was within normal limits in all cases and total and specific IgE concentrations were increased only on one case. The decreased STF activity may be responsible for a possible impairment of cell-mediated immunity and for the increased stimulation of the reaginic system observed in asthmatic patients, via its effects on some T cell subpopulation, namely, suppressor T lymphocytes, which seem particularly sensitive to STF variations. On the basis of these data and of the results of our study, a possible, although speculative, correlation between reduced STF activity and high IgE concentrations in asthmatic patients may be postulated. The reported increased occurrence of autoimmune phenomena in asthmatic patients is in agreement with the hypothesis of a STF-mediated suppressor T-lymphocyte quantitative and/or qualitative defect in this disease.
    Digital Access Access Options