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  • Book
    edited by Gerd Gigerenzer and J.A. Muir Gray.
    Contents:
    Health literacy : is the patient the problem?
    Launching the century of the patient / Gerd Gigerenzer and J.A. Muir Gray
    When misinformed patients try to make informed health decisions / Wolfgang Gaissmaier and Gerd Gigerenzer
    Reducing unwarranted variation in clinical practice by supporting clinicians and patients in decision making / Albert G. Mulley, Jr., and John E. Wennberg
    Do patients want shared decision making and how is this measured? / Martin Hañrter and Daniela Simon
    Health illiteracy : roots in research
    Health research agendas and funding / David E. Nelson
    Reporting of research : are we in for better health care by 2020? / Holger Schanemann, Davina Ghersi, Julia Kreis, Gerd Antes, and Jean Bousquet
    Medical journals can be less biased / J.A. Muir Gray
    What is needed for better health care : better systems, better patients or both? / Markus A. Feufel, Gerd Antes, Johann Steurer, Gerd Gigerenzer, J.A. Muir Gray, Marjukka MÃñkelÃñ, Albert G. Mulley, Jr., David E. Nelson, Jay Schulkin, Holger Schanemann, John E. Wennberg, and Claudia Wild
    Health illiteracy : spread to the public
    Statistical illiteracy in doctors / Odette Wegwarth and Gerd Gigerenzer
    Statistical illiteracy in journalism : are its days numbered? / Bruce Bower
    Improving health care journalism / Holger Wormer
    Barriers to health information and building solutions / Talya Miron-Shatz, Ingrid Mahlhauser, Bruce Bower, Michael Diefenbach, Ben Goldacre, Richard S.W. Smith, David Spiegelhalter, and Odette Wegwarth
    Health care 2020
    How can better evidence be delivered? / Norbert Donner-Banzhoff, Hilda Bastian, Angela Coulter, Glyn Elwyn, Gunther Jonitz, David Klemperer, and Wolf-Dieter Ludwig
    The drug facts box : making informed decisions about prescription drugs possible / Lisa M. Schwartz and Steven Woloshin
    Reengineering medical education / David A. Davis
    The chasm between evidence and practice : extent, causes, and remedies / Richard S.W. Smith
    The future of diagnostics : from optimizing to satisficing / Henry Brighton
    Direct-to-consumer advertising : status quo and suggestions to enhance the delivery of independent medication information / Wolf-Dieter Ludwig and Gisela Schott
    How will health care professionals and patients work together in 2020? : a manifesto for change / Ralph Hertwig, Heather Buchan, David A. Davis, Wolfgang Gaissmaier, Martin Harter, Kai Kolpatzik, France LÃgarÃ, Norbert Schmacke, and Holger Wormer.
    Digital Access eBook Comp Acad 2011
  • Article
    Broxmeyer HE, Smithyman A, Eger RR, Meyers PA, de Sousa M.
    J Exp Med. 1978 Oct 01;148(4):1052-67.
    Lactoferrin (LF), the iron-binding protein present in the specific granules of mature granulocytes has been identified as colony inhibitory factor (CIF) which suppresses granulocyte--macrophage colony stimulating activity (CSA) production by monocytes and macrophages in vitro and rebound granulopoiesis in vivo. Separation of LF and CIF by isoelectric focusing confirmed that the regions of inhibitory activity corresponded in both to a pH of congruent to 6.5. In addition, the purified immunoglobulin fraction of rabbit anti-human LF antiserum, but not rabbit anti-transferrin (TF), inactivated the capacity of LF and CIF to inhibit CSA production, an effect blocked by prior incubation of anti-LF with neutralizing concentrations of LF. Suppression of CSA production correlated with the iron-saturation of LF; APO-LF (depleted of iron) was only active concentrations greater than 10(-7) M, native LF (8% iron saturated) was active at 10(-15) M, and fully iron-saturated LF inhibited at 10(-17) M. Suppression of CSA production occurred within a 1/2-h preincubation period with human blood monocytes but was reversed by bacterial lipopolysaccharide (LPS). This reversal was dependent on the relative concentrations of LF to LPS. Serum TF, a biochemically similar iron-binding protein which is antigenically distinct from LF, was only minimally active at concentrations greater than 10(-6) M. LF did not inhibit exogenously stimulated human granylocyte and macrophage colony-forming cells or erythropoietin-dependent human or murine erythroid colony- or erythroid burst-forming cells. Microgram quantities of LF acted in vivo to inhibit rebound granulopoiesis and CSA production in CD1 and C57Bl/6 mice pretreated with cyclophosphamide. These results strongly implicate LF as a physiological regulator of granulopoiesis.
    Digital Access Access Options