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- ArticleZakharova MS, Sokolovskaia AD, Shavrova EN.Zh Mikrobiol Epidemiol Immunobiol. 1978 Apr(4):73-6.Experiments were conducted on mice, strain NIH, line HSFS/N, immunized with pertussis vaccine. Determination of thymocyte pool proved to be a more sensitive method of detection of the stress effect of the vaccine than determination of the thymus weight. The test can be used for the elaboration of the method of assessment of the toxicity of pertussis preparations.