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  • Book
    David J. Browning.
    Summary: "Malpractice settlements are large for undetected hydroxychloroquine and chloroquine toxicity which, if untreated, can lead to permanent loss of central vision. Knowledge of the ocular toxicity of these drugs has increased during the past fifty years as their use has expanded. Hydroxychloroquine and Chloroquine Retinopathy is the first single-source book on the subject and is essential for the practicing ophthalmologists, rheumatologists, dermatologists, and internists who prescribe these drugs. It covers clinical topics such as signs and symptoms of toxicity, toxicity screening, ancillary testing, to whom and why the drugs are prescribed and dosing considerations. Additionally, the book addresses practice management considerations, including coding, reimbursement and equipment costs, and the medico-legal responsibilities of the rheumatologist and of the ophthalmologist. Guidelines for the management of hydroxychloroquine and chloroquine vary around the world and differences between the guidelines of the United Kingdom, the United States, and other countries are identified. The book concludes with a collection of case examples illustrating common clinical scenarios and their management. This book is a “must-have” resource for physicians who use these drugs."--Publisher's website.
    Digital Access Springer 2014
  • Article
    Shipov AA, Ovechkin VG.
    Kosm Biol Aviakosm Med. 1978 Sep-Oct;12(5):68-72.
    As a result of experiments on Wistar, Wistar-SPF and mongrel rats, the duration, number of beats and frequency of nystagmus in response to progressively increasing acceleration of 10, 20, 30 and 40 deg/sec2 for 3 sec at each step were determined. These parameters were found to increase with a rise in acceleration, the rate of increase being gradually slowed down (the slope of the curves decreased). The number of beats and the duration of the nystagmus in the Wistar and mongrel rats were identical and significantly higher (P less than 0.01) than those in the Wistar-SPF rats. There was no difference in the nystagmic frequency. It was demonstrated that the system of animal restraint produced a noticeable effect on the quantitative characteristics of the nystagmus, e. g. duration and number of beats. The paper describes a system of gentle restraint of rats.
    Digital Access Access Options