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  Fire Defense Section Bulletin

  United States Office of Civilian Defense.

  Contents:
  No.
  1. Fire defense organization.

  Access via [Collection of publications from the U.S. Office of Civilian Defense] ; 1942; 21.

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  [Collection of publications from the U.S. Office of Civilian Defense] ; 1942; 21.

  1942-

  L983 .U531 no.21 1942-
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• Article

  Differential endotoxin sensitivity of lymphocytes and macrophages from mice with an X-linked defect in B cell maturation.

  Rosenstreich DL, Vogel SN, Jacques A, Wahl LM, Scher I, Mergenhagen SE.

  J Immunol. 1978 Aug;121(2):685-90.

  The in vitro sensitivity of B lymphocytes and macrophages derived from (CBA/N X DBA/2N) F1 male mice, which carry an X-linked recessive gene that produces defective B cell maturation, was compared to phenotypically normal F1 female mice. B lymphocytes of F1 males exhibit an abnormal mitogenic response to LPS in serum-free culture conditions, which is partially reversed in the presence of serum. In contrast, both resident and thioglycollate-induced peritoneal macrophages of F1 male mice respond normally to LPS. In response to LPS in vitro, F1 male macrophages produce the monokine, lymphocyte-activating factor (LAF) and release prostaglandins. Furthermore, F1 male macrophages are sensitive to the lethal effects of LPS. Therefore, the defective CBA/N gene appears to be expressed only in B lymphocytes and not in macrophages. Since F1 male mice are normally sensitive to the lethal and adjuvant effects of LPS in vivo, these findings suggest that a mature B lymphocyte population is not required for these effects and support the role of the macrophage in the mediation of LPS-induced lethality and adjuvanticity.

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