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  • Book
    Ary L. Goldberger, Zachary D. Goldberger.
    Summary: "The Consummate Clinician offers hospital-based physicians an organizing framework for coping with daily challenges both in patient care and in teaching. The book describes in a highly formatted, easily accessible way exactly how physicians and physicians-in-training can think critically and act decisively in this age of medical information overload. Special emphasis is on (1) error avoidance and reduction - a topic that has long been championed by hospitalists, (2) efficient practice management for best patient outcomes and improved cost control, (3) the use of evidence-based medicine, and (4) improving communication among and between physicians and other staff in the hospital setting. Using real-world clinical examples and scenarios, the book focuses on essential topics, many of which tend to fall between the cracks of print and electronic resources. Pearls and pitfalls of gathering, processing, and communicating medical information are presented, but more than these, this book is meant as a kind of clinical GPS--a way of helping hospital-based physicians find their clinical coordinates and keep their bearings in the face of new challenges and uncertainties. In addition to the clinical scenarios featured throughout, additional mini-cases are collected at the end of the book. The over-arching goal of this new resource is to enrich the way hospital-based physicians think about diagnosis, therapy, and prognosis, especially at the warp-speed of "ward world," which increasingly lurches between the frazzled and the frantic"--Provided by publisher.

    Contents:
    Introduction: Surviving and Thriving in Ward World
    Medical Musts and Must-Nots: Six Essentials of Ward World. How (Not) to Present a Patient History
    Reexamining the Physical Exam
    How (Not) to Order and Present Lab Tests
    Seeing is (Almost) Believing: The Importance of Reviewing Data
    'Worsts First': How to Frame a Differential Diagnosis
    Clinical Queries: Asking the 3 1/2 Key Questions
    Medical Masteries. : Error Reduction Equals Motivation Times Communication to the Power of 3
    Evidence-Based Medicine: What and Where is the Evidence?
    Caution! Dangerous Biomedical Semantics at Work
    Some Second Opinions: Outliers, Hoofbeats, and Sutton's (Flawed) Law
    A Sixfold Path: From Data to Knowledge to Understanding
    What is Disease? What is Health?.
    Digital Access Wiley c2012
  • Article
    Pazdernik TL, Nishimura T.
    Agents Actions. 1978 Apr;8(3):229-37.
    X-irradiation was used as a tool to investigate the radiosensitivity of different B and T precursor subpopulations as detected by three in vitro culture systems. The culture systems utilized in this study included antigen reactive cell assays (ARCA), polyclonal mitogen assays (PMA), and polyclonal effector cell assays (PECA). The order of radiosensitivity of these systems in both the B and T cell series was ARCA greater than PMA greater than PECA (D37 values for B cell responses: ARCA = 88.8 R, PMA = 125 R, PECA = 223 R; D37 values for T cell responses: ARCA = 160 R, PMA = 441 R and PECA = 1095 R). With all assay systems the B cell response was more radiosensitive than the T cell response. The extrapolation number (n) from the radiation survival curves was approximately 2.0 for T cell responses and approximately 1.0 for B cell responses. The value of 1.0 for B cell responses suggest that their extreme radiosensitivity may be due in part to a lack of repair mechanisms. These findings also suggest that the more primitive precursor cells are more apt to undergo cellular proliferation upon activation and that this event is more radiosensitive than is the final differentiation event of precursor cells into a progeny of functional end-stage cells.
    Digital Access Access Options