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- ArticleZabik JE, Liao SS, Jeffreys M, Maickel RP.Res Commun Chem Pathol Pharmacol. 1978 Apr;20(1):69-78.Rats were offered access to either distilled water or a 12% v/v solution of ethanol as their only fluid during a one hour period daily. After daily fluid consumption has achieved a stable baseline, either distilled water or DL-5-hydroxytryptophan (5HTP) in doses of 50, 100 or 200 mg/kg was injected intraperitoneally one hour prior to the drinking session. While each of the three doses of 5HTP caused a significant reduction in ethanol intake, distilled water had no effect. Water consumption was unaffected by 5HTP or distilled water injections. Varying the pretreatment interval from 0.5, 1, 4 to 8 hours for the 100 mg/kg 5HTP dose resulted in a significant decrease in ethanol consumption at 0.5 and 1 hour pretreatment intervals only. In approximately 25% of the rats tested, 5HTP resulted in a prolonged rejection of ethanol so severe that it resulted in death. Selected rats offered water during this ethanol rejection period readily drank it and survived.
- BookLars Kaestner.Contents:
Summary
Introduction
Direct evidence - the digital approach
Fluorescence-based visualisation
Aequorin-based measurements
Measurement of calcium transport across membranes
Molecular biology based approaches
Manipulation of calcium
Calcium-induced function
Calcium signalling in cardiac myocytes
Calcium signalling in red blood cells
Perspective
Calcium Signalling Methodology
Non-linear and ultra high-speed imaging for explorations of the murine and human heart
A system for optical high resolution screening of electrical excitable cells
Concepts for optical high content screens of excitable primary isolated cells
A primary culture system for sustained expression of a calcium sensor in preserved adult rat ventricular myocytes
Calcium imaging of individual erythrocytes: Problems and approaches
Calcium Signalling in Cardiac Myocytes
Reduced Cardiac L-Type Ca²+ Current in Cav€ ₂ -/- Embryos Impairs Cardiac Development and Contraction With Secondary Defects in Vascular Maturation
Overexpression of junctin causes adaptive changes in cardiac myocyte Ca²+ signaling
Remodelling of Ca²+ handling organelles in adult rat ventricular myocytes during longterm culture
Functional and morphological preservation of adult ventricular myocytes in culture by sub-micromolar cytochalasin D supplement
Calcium Signalling in Red Blood Cells
The non-selective voltage-activated cation channel in the human red blood cell membrane: reconciliation between two conflicting reports and further characterisation
Ion channels in the human red blood cell membrane: Their further investigation and physiological relevance
Prostaglandin E₂ activates channelmediated calcium entry in human erythrocytes: An indication for a blood clot formation supporting process
Functional NMDA receptors in rat erythrocytes
Stimulation of human red blood cells leads to Ca²+-mediated intercellular adhesion
Lysophospatidic acid induced red blood cell aggregation in vitro
Regulation of phosphatidylserine exposure in red blood cells
Cation Channels in Erythrocytes - Historical and Future Perspective.Digital Access Springer 2013