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  • Book
    V. Sree Hari Rao, Ravi Durvasula, editors.
    Summary: This book covers modeling of insect vector-borne infectious diseases, which account for some three million deaths worldwide. The authors describe processes for quantifying the vital parameters of diseases transmitted by mosquitoes, sand flies, fleas and ticks. Despite great advances in public health worldwide, insect vector-borne infectious diseases remain a leading cause of morbidity and mortality. Diseases that are transmitted by arthropods such as mosquitoes, sand flies, fleas, and ticks affect hundreds of millions of people and account for nearly three million deaths all over the world. In the past there was very little hope of controlling the epidemics caused by these diseases, but modern advancements in science and technology are providing a variety of ways in which these diseases can be handled. Clearly, the process of transmission of an infectious disease is a nonlinear dynamic process which can be understood only by appropriately quantifying the vital parameters that govern these dynamics.
    Digital Access Springer 2013
  • Article
    Legerski RJ, Hodnett JL, Gray HB.
    Nucleic Acids Res. 1978 May;5(5):1445-64.
    We have previously characterized an extracellular nuclease from Pseudomonas BAL 31 which, in addition to other activities, displays a double-strand exonuclease activity which progressively shortens both strands of linear duplex DNA molecules from both termini. This degradation is accomplished without the introduction of detectable scissions away from the ends of the duplexes. When this nuclease is used to produce a series of progressively shortened samples from a linear duplex DNA, subsequent digestion of these samples with a site-specific restriction endonuclease and analysis of the resulting fragments by gel electrophoresis permits the rapid establishment of the order of the restriction enzyme fragments through the entire genome. This is accomplished by noting from the electropherograms the order in which the various restriction enzyme fragments become noticeably shortened or disappear. Using this method, the five cleavage sites for the endonuclease Hpa I and the single cleavage sites for the nucleases Hpa II and Pst I have been mapped in PM2 bacteriophage DNA. In a more stringent test of the method, 18 of the 24 fragments produced by cleavage of coliphage lambdab2b5c DNA with the Pst I nuclease have been mapped, and five of the six remaining fragments have been assigned to small regions of the genome.
    Digital Access Access Options