BookPaul J. Fairchild, editor.
Summary: Recent years have witnessed numerous advances in stem cell research that have suggested novel strategies for the treatment of the chronic and regenerative diseases that pose a growing challenge to the provision of healthcare in the 21<sup>st</sup> century. Nevertheless, there is little doubt that related disciplines have failed to keep pace with such developments, of which the immunology of transplant rejection is perhaps the most relevant to the nascent field of regenerative medicine. Indeed, given that after decades of research into the mechanisms of organ allograft rejection, we remain wholly dependent on immune suppression to ensure acceptance of foreign tissues, we might legitimately ask whether there is any reason why tissues differentiated from stem cells might not suffer the same fate. This volume seeks to address this issue by drawing on the principles of alloantigen recognition to assess the validity of early convictions that embryonic stem cell-derived tissues may prove invisible to the immune system of the host and the more recent belief that induced pluripotent stem cells, derived in a fully autologous manner, will circumvent the issue of immunogenicity. Having debunked such assumptions and established the magnitude of the immunological barriers to be overcome, this book then draws on the expertise of internationally-recognised laboratories around the world to provide a critical assessment of the likely success of applying strategies such as stem cell banking, silencing of genes that confer immunogenicity, and the induction of transplantation tolerance to overcoming the immunological barriers in the future. Indeed, it is only through reaching a consensus in the field that enduring solutions to such an intractable problem may ultimately emerge.
Contents:
Mechanisms of Immune Rejection of Stem Cell-Derived Tissues: Insights from Organ Transplantation
The Immunogenicity of ES Cells and their Progeny
Interaction of Embryonic Stem Cells with the Immune System
The Role of NK cells and T Cells in the Rejection of Embryonic Stem Cell-Derived Tissues
Mitigating the Risks of Immunogenicity in the Pursuit of Induced Pluripotency
Thymic Involution: A Barrier or Opportunity for Cell Replacement Therapy?
Construction of Stem Cell Banks: Prospects for Tissue Matching
Generation of Histocompatible Tissues via Parthenogenesis
Prospects for Designing 'Universal' Stem Cell Lines
The Immunosuppressive Properties of Adult Stem Cells: MSC as a Case Study
The Immunogenicity of Stem Cells and Thymus-Based Strategies to Minimise Immune Rejection
The Induction of Mixed Chimerism Using ES Cell-Derived Hematopoietic Stem Cells
Prospects for the Induction of Transplant Tolerance Using Dendritic Cells
Strategies for the Induction of Tolerance with Monoclonal Antibodies
Induction of Immunological Tolerance to Transgene Products
Addressing the Challenge of Autoimmunity in the Treatment of Diabetes with Stem Cells.