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  • Book
    Thomas Boehm, Yousuke Takahama, editors.
    Summary: The thymus is an evolutionarily ancient primary lymphoid organ common to all vertebrates in which T cell development takes place. Failing thymus function is associated with immunodeficiency and/or autoimmunity. In this volume, leading experts provide a comprehensive overview of recent advances in thymopoiesis research. The chapters cover the development of the thymic epithelial microenvironment, address the formation of a diverse and self-tolerant repertoire of T cell receptors as the basis for cellular immunity, discuss the mechanisms by which progenitor cells colonize the thymus and detail the molecular basis for T lineage decisions. The reviews illustrate the important role of the multifaceted process of thymopoiesis for adaptive immunity.

    Contents:
    Development and Function of Cortical Thymic Epithelial Cells
    Mechanisms of Thymus Medulla Development And Function
    Self-peptides in TCR Repertoire Selection and Peripheral T Cell Function
    Central Tolerance Induction
    Trafficking to the Thymus
    The CD4/CD8 Lineages: Central Decisions and Peripheral Modifications for T Lymphocytes.
    Digital Access Springer 2014
    Access via Current topics in microbiology and immunology ; 2014; 373
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    Current topics in microbiology and immunology ; 2014; 373
    2014
  • Article
    Krüger J, Desaga FJ.
    Blut. 1978 Jun 20;36(6):315-23.
    As part of an overall assessment of immunological function, several aspects of cellular immunity and circulating lymphocyte subpopulations were evaluated in a group of 10 patients with idiopathic autoimmunhemolytic anemia (AIHA). The absolute numbers of circulating T and B cells were reduced in the patient group compared to normals. A shift from "corticosteroid-sensitive" to "corticosteroid-resistent" and activated cells in the cytogram of clustered Fe-(III)-hydroxide-glucane saccharose labeled T lymphocytes was apparent. In vitro studies of cellular reactivity, as evaluated by PHA, ConA, PWM, antigens and allogeneic cell induced proliferation showed a blend of general or selective depression and sometimes a normal or increased activity with no definite correlation with both the number of circulating T cells and the extent of the hemolytic activity by the disease. The possible significance of the findings is discussed.
    Digital Access Access Options