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- BookJun Chen, Xiaoming Hu, Mary Stenzel-Poore, John H. Zhang, editors.Summary: Recent research has revealed the importance of immunological mechanisms and inflammation in delaying damage and/or promoting repair after an acute injury to the central nervous system. This book provides a comprehensive and up-to-date overview of the role of immunological mechanisms and therapies for treating acute neurological injuries such as cerebral ischemia, hemorrhage, and brain and spinal cord trauma. In several sections, the contributing authors provide a review of immunological mechanisms involved in neurological injury and of various translational and clinical research aimed at harnessing those mechanisms for better patient outcomes.
Contents:
Old dogmas, surprising complexities, and novel therapeutic targets
The critical roles of immune cells in acute brain injuries
Vascular Inflammation in Ischemic Stroke: Adhesion Receptors Controlling Leukocyte-Endothelial Interactions
Immune Cell-Derived Free Radicals in Acute Brain Injury
The complement cascade in acute brain injury
Matrix Metalloproteinases as an Inflammatory Mediator in the Neurovascular Unit
Toll-Like Receptors in Ischemic Stroke and other Acute Brain Injuries
Ion Transporters in Microglial Function: New therapeutic targets for neuroinflammation in ischemic stroke?
Inflammation After Acute Brain Injuries Affects the Developing Brain Differently than the Adult Brain
Systemic Immune Responses after Experimental Stroke
Infectious Burden and Risk of Stroke
Inflammatory Biomarkers in Patients with Acute Brain Injuries
In vivo Imaging of Neuroinflammation in Acute Brain Injury
Inflammation as a therapeutic target after subarachnoid hemorrhage: advances and challenges
Minocycline, a Tetracycline Derivative, as a Potential Protective Agent for Acute Stroke
Tolerization to Brain and Vascular Antigens: Targeting Autoimmunity after Acute Brain Injuries and Preventing Stroke
The Role of PPARg in Stroke
CD36: an inflammatory mediator in acute brain injury
Cool Down the Inflammation: Hypothermia as a Therapeutic Strategy for Acute Brain Injuries. - ArticleNistri A, Morelli P.Neuropharmacology. 1978 Jan;17(1):21-7.