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  • Book
    Christian R. Landry, Nadia Aubin-Horth, editors.
    Summary: "Researchers in the field of ecological genomics aim to determine how a genome or a population of genomes interacts with its environment across ecological and evolutionary timescales. Ecological genomics is trans-disciplinary by nature. Ecologists have turned to genomics to be able to elucidate the mechanistic bases of the biodiversity their research tries to understand. Genomicists have turned to ecology in order to better explain the functional cellular and molecular variation they observed in their model organisms. Ecological genomics covers 3 fields of research that have most benefited from the recent technological and conceptual developments in the field of ecological genomics: the study of life-history evolution and its impact of genome architectures; the study of the genomic bases of phenotypic plasticity and the study of the genomic bases of adaptation and speciation"-- Publisher's description.

    Contents:
    Recent advances in ecological genomics: from phenotypic plasticity to convergent and adaptive evolution and speciation
    Trait transitions in explicit ecological and genomic contexts: plant mating systems as case studies
    Revisiting Mortimer's genome renewal hypothesis: heterozygosity, homothallism, and the potential for adaptation in yeast
    Ecological genomics of adaptation and speciation in Fungi
    Integrating phenotypic plasticity within an ecological genomics framework: recent insights from the genomics, evolution, ecology, and fitness of plasticity
    Eco-evo-devo: the time has come
    Evolutionary and ecological genomics of developmental plasticity: novel approaches and first insights from the study of horned beetles
    Neurogenomics of behavioral plasticity
    Ecological genomics of host behavior manipulation by parasites
    Ecological epigenetics
    The reproducibility of adaptation in the light of experimental evolution with whole genome sequencing
    Ecological Genomics of Host Shifts in Drosophila mojavensis
    The genomics of an adaptive radiation
    insights across the Heliconius speciation continuum
    Merging ecology and genomics to dissect diversity in wild tomatoes and their relatives
    Integrated genomics approaches in evolutionary and ecological endocrinology
    Evolutionary genomics of environmental pollution
    Signatures of natural selection and ecological differentiation in microbial genomes.
    Digital Access Springer 2014
    Access via Advances in experimental medicine and biology ; 2014 ; 781
    Location
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    Items
    Advances in experimental medicine and biology ; 2014 ; 781
    2014
  • Article
    Neher E, Steinbach JH.
    J Physiol. 1978 Apr;277:153-76.
    1. Single channel currents through acetylcholine receptor channels (ACh channels) were recorded at chronically denervated frog muscle extrajunctional membranes in the absence and presence of the lidocaine derivatives QX-222 and QX-314. 2. The current wave forms due to the opening and closing of single ACh channels (activated by suberyldicholine) normally are square pulses. These single pulses appear to be chopped into bursts of much shorter pulses, when the drug QX-222 is present in addition to the agonist. 3. The mean duration of the bursts is comparable to or longer than the normal channel open time, and increases with increasing drug concentration. 4. The duration of the short pulses within a burst decreases with increasing drug concentration. 5. It is concluded that drug molecules reversibly block open end-plate channels and that the flickering within a burst represents this fast, repeatedly occurring reaction. 6. The voltage dependence of the reaction rates involved, suggested that the site of the blocking reaction is in the centre of the membrane, probably inside the ionic channel.
    Digital Access Access Options