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  • Book
    Victor P. Eroschenko.
    Contents:
    Histologic methods
    Light and transmission electron microscopy
    Cells and the cell cycle
    Epithelial tissue
    Connective tissue
    Hematopoietic tissue
    Skeletal tissue : cartilage and bone
    Muscle tissue
    Nervous tissue
    Circulatory system
    Immune system
    Integumentary system
    Digestive system part I : oral cavity and major salivary glands
    Digestive system part II : esophagus and stomach
    Digestive system part III : small and large intestines
    Digestive system part IV : accessory digestive organs
    Respiratory system
    Urinary system
    Endocrine system
    Male reproductive system
    Female reproductive system
    Organs of special senses : visual and auditory systems.
    Print Access Request
    Location
    Version
    Call Number
    Items
    Books: General Collection (Downstairs)
    2013
    QM557 .F5513 2013
    1
  • Article
    Bodel P.
    J Exp Med. 1978 May 01;147(5):1503-l6.
    Tumor-associated fever occurs commonly in acute leukemias and lymphomas. We investigated the capacity for in vitro production of pyrogen by three mouse histiocytic lymphoma cell lines (J-774, PU5-1.8, p 388 D1), one myelomonoyctic line (WEHI-3), and tow lymphoma-derived lines, RAW-8 and R-8. Pyrogen was released spontaneously into the culture medium during growth by all cell lines with macrophage or myeloid characteristics including lysozyme production; R-8 cells, of presumed B-lymphocyte origin, did not produce pyrogen. When injected into mice, the pyrogens gave fever curves typical of endogenous pyrogen, were inactived by heating to 56 degrees C and by pronase digestion, and appeared to be secreted continuously by viable cells. Two pyrogenic molecular species produced by H-774 cells were identified by Sephadex filtration, one of mol wt approximately equal to 30,000, and the other greater than or equal to 60,000. By contrast, three carcinoma cell lines of human origin and SV-40 3T3 mouse fibroblasts did not produce pyrogen in vitro. These results suggest that some malignant cells derived from phagocytic cells of bone marrow origin retain their capacity for pyrogen production, and may spontaneously secrete pyrogen during growth.
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