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• Journal

  Interventional Medicine & Applied Science

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  PubMed Central

  v. 4, no. 4-v. 11, Dec. 2012-20.

  Akad Kiado

  v. 6, no. 4-v. 11, Dec. 2014-19.
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• Article

  Molecular basis of B cell activation: mitogenicity of native and modified digitalis glycosides.

  Hammarström LL, Smith CI.

  J Immunol. 1978 Mar;120(3):694-9.

  Lanatoside C, a digitalis glycoside, has previously been shown to be a potent polyclonal B cell activator for mouse lymphocytes. Since the chemical structure of lanatoside C is well defined we investigated the effect of different chemical modifications on the mitogenic properties of the glycoside in order to determine the molecular basis of B cell activation. The presence of an OH- group at C12 in the steroid nucleus proved to be essential for activation to occur in serum-free medium. Likewise, an intact carbohydrate side chain at C3 appeared to be necessary for retaining mitogenic properties. In serum-supplemented cultures, however, a much more complex response pattern was observed where the prerequisites for activation were not as distinct as in serum-free medium.

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