ArticleDonner M, Bischoff P, Lacour F.
Dev Biol Stand. 1977 Apr 13-15;38:159-65.
Spleens and thymuses of mice were examined for changes in lymphocyte subpopulations after in vivo treatment with a double stranded synthetic polynucleotide: Poly A.Poly U. The cell populations were characterized on a biophysical basis: the electrical charge of cell surface assessed by the anodic electrophoretic mobility. The proportion of spleen cells exhibiting a high electrophoretic mobility (T lymphocytes) increased markedly on the 3rd day after a single intravenous injection of Poly A.Poly U. In thymuses, early important variations in electrophoretic distribution profiles were observed after Poly A.Poly U injection, suggesting that adjuvant acts on T cells.