BookAndreas Rummel, Thomas Binz, editors.
Summary: The extremely potent substance botulinum neurotoxin (BoNT) has attracted much interest in diverse fields. Originally identified as cause for the rare but deadly disease botulism, military and terrorist intended to misuse this sophisticated molecule as biological weapon. This caused its classification as select agent category A by the Centers for Diseases Control and Prevention and the listing in the Biological and Toxin Weapons Convention. Later, the civilian use of BoNT as long acting peripheral muscle relaxant has turned this molecule into an indispensable pharmaceutical world wide with annual revenues >$1.5 billion.
Contents:
Genetic Diversity Within Clostridium botulinum Serotypes, Botulinum Neurotoxin Gene Clusters and Toxin Subtypes / Karen K. Hill, Theresa J. Smith
Assembly and Function of the Botulinum Neurotoxin Progenitor Complex / Shenyan Gu, Rongsheng Jin
Uptake of Botulinum Neurotoxin in the Intestine / Yukako Fujinaga, Yo Sugawara, Takuhiro Matsumura
Double Receptor Anchorage of Botulinum Neurotoxins Accounts for their Exquisite Neurospecificity / Andreas Rummel
The Elusive Compass of Clostridial Neurotoxins: Deciding When and Where to Go? / Kinga Bercsenyi, Francesco Giribaldi, Giampietro Schiavo
Synchronized Chaperone Function of Botulinum Neurotoxin Domains Mediates Light Chain Translocation into Neurons / Audrey Fischer
Clostridial Neurotoxin Light Chains: Devices for SNARE Cleavage Mediated Blockade of Neurotransmission / Thomas Binz
Synaptic Vesicle Proteins: Targets and Routes for Botulinum Neurotoxins / Gudrun Ahnert-Hilger, Agnieszka Münster-Wandowski, Markus Höltje
Persistence of Botulinum Neurotoxin Inactivation of Nerve Function / Charles B. Shoemaker, George A. Oyler
Structure-Based Drug Discovery for Botulinum Neurotoxins / Subramanyam Swaminathan
Complexity of Botulinum Neurotoxins: Challenges for Detection Technology / Martin B. Dorner, K. Melanie Schulz, Skadi Kull
Progress in Cell Based Assays for Botulinum Neurotoxin Detection / Sabine Pellett
Transforming the Domain Structure of Botulinum Neurotoxins into Novel Therapeutics / John Chaddock
Botulinum Toxin: Application, Safety, and Limitations / Hans Bigalke.
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