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  Digital Access ProQuest v. 1-50, 1946-95.
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  Effect of levamisole on autologous rosette-forming cells in nude mice.

  Van Wauwe J, Van Nijen G.

  Clin Exp Immunol. 1977 Dec;30(3):465-8.

  Levamisole depresses the number of autologous rosette-forming cells (ARFC) in the spleen of nude (congenitally athymic) mice. Intravenous administration of 2.5 mg/kg of levamisole produces maximal depression. This effect appears 15 h after injection and is transient, partially disappearing after 48 hr. Dexamisole is devoid of this depressing activity. Thymopoietin, a thymic hormone, is also shown to lower the level of autologous rosette formation. These results suggest a stereospecific interference of levamisole with the maturation of immature T-cell precursors in a manner resembling the action of thymic hormones.

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