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  • Book
    edited by Robin Ganellin, Stanley Roberts, Roy Jefferis.
    Contents:
    Chapter 1. Introduction to enzymes, receptors and the action of small molecule drugs
    chapter 2. Protein structure and function
    chapter 3. The small molecule drug discovery process : from target selection to candidate selection
    chapter 4. Protein therapeutics (introduction to biopharmaceuticals)
    chapter 5. Similarities and differences in the discovery and use of biopharmaceuticals and small-molecule chemotherapeutics
    chapter 6. Therapies for type 2 diabetes : modulating the incretin pathway using small molecule peptidase inhibitors or peptide mimetics
    chapter 7. The structure and business of biopharmaceutical companies including the management of risks and resources
    chapter 8. Discovery and development of the anticancer agent gefitinib, an inhibitor of the epidermal growth factor receptor tyrosine kinase
    chapter 9. Targeting HER2 by monoclonal antibodies for cancer therapy
    chapter 10. Recombinant human erythropoietin and its analogues
    chapter 11. Lysosomal storage disorders : current treatments and future directions
    chapter 12. Hormone replacement therapy
    chapter 13. Design of the anti-HIV protease inhibitor darunavir
    chapter 14. The case of anti-TNF agents
    chapter 15. Discovery of the cholesterol absorption inhibitor, ezetimibe.
    Digital Access ScienceDirect 2013
  • Article
    Sultan C, Imbert M, Ricard MF, Sebaoun G, Marquet M, Brun B, Forgues L.
    Am J Clin Pathol. 1977 Dec;68(6):752-7.
    Twelve cases of pure acute monocytic leukemia in adults were studied. They were selected on the basis of the morphology of the blast cells on Romanowsky-stained smears of blood and bone marrow, as well as positivity of the cells for the naphthol ASD acetate esterase reaction specifically inhibited by sodium fluoride. There was no sex predominance. Neoplastic involvement of the skin and/or gingiva was very frequent. The leukemic proliferation in blood and bone marrow consisted of monoblasts, promonocytes and monocytes. The peroxidase reaction was negative or only faintly positive. Serum and urinary lysozyme levels were increased. The blast cells retained their ability to stimulate, in vitro, colony formation by normal bone marrow cells used as targets. All of these characteristics permit specific identification of this type of acute leukemia. The prognosis is grim: only five of 12 patients achieved complete remission, and four of these five had relapses in less than 14 months; the median survival was five months.
    Digital Access Access Options