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- ArticleRoliński Z.Pol J Pharmacol Pharm. 1977 Nov-Dec;29(6):591-602.The aggression--stereotypy complex (ASC) was produced in mice by administration of 15 mg/kg of amphetamine. The elevation of cerebral serotonin level in the mouse brain by administration of L-tryptophan or DL-5-hydroxytryptophan suppressed the aggressiveness without affecting significantly the stereotypy. Serotonin antagonists: methysergide and cyproheptadine, did not potentiate clearly the aggressive component of ASC. Cholinomimetics, pilocarpine and physostigmine, strongly suppressed the aggressive component, while a cholinolytic, scopolamine, evidently potentiated the elements of aggressive behavior. The aggressiveness observed in the ASC in the mouse receiving a large dose of amphetanine is predominantly dependent on the increase of activity of dopaminergic system, but seems to be functionally dependent also on the serotonergic and cholinergic systems.