BookFrancine Foss, editor.
Summary: The mature T and NK cell lymphomas are rare, comprising approximately 10% of all malignant lymphomas. The incidence of T-cell lymphoma is variable around the world, with a higher incidence compared to B-cell lymphomas in the Asian basin. While the overall incidence of B-cell lymphomas has begun to decline in the United States, the incidence of T-cell lymphomas continues to rise. Over the last decade, a number of novel agents have been developed which target T-cell lymphomas and studies have identified novel genes and pathways associated with lymphomagenesis in T-cells. This comprehensive volume examines the clinical and biological aspects of the T-cell lymphoproliferative disorders in adults and children. The book includes an overview of both the cutaneous and the systemic T-cell malignancies and addresses the classification of T-cell lymphomas, the clinical features of each subtype, and the relevant molecular and genetic studies. Clinical outcomes and treatment strategies are discussed with an emphasis on the development of novel biological and targeted therapies. An outstanding resource for hematologists and oncologists, this book gathers insights from experts in the field and provides the most up-to-date information on all of the T-cell lymphoma subgroups and current and emerging therapies.
Contents:
Histopathology and Classification of T-Cell Lymphomas / Claudiu V. Cotta and Eric D. Hsi
Epidemiology and Prognosis of T-Cell Lymphoma / Sophia S. Wang and Julie M. Vose
Molecular Profiling and Prognosis in T-Cell Lymphomas / Pier Paolo Piccaluga and Stefano Aldo Pileri
Molecular and Clinical Aspects of Angioimmunoblastic T-Cell Lymphoma / Laurence de Leval, Francine Foss and Philippe Gaulard
Primary Cutaneous and Systemic CD30+ T-cell Lymphoproliferative Disorders / Marshall E. Kadin and Francine Foss
NK-Cell Neoplasms / Motoko Yamaguchi and Kensei Tobinai
Rare Subtypes of Extranodal T-Cell Lymphoma / Frederick Lansigan, S. David Hudnall and Francine Foss
HTLV-1-Associated T-cell Diseases / Kunihiro Tsukasaki and Kensei Tobinai
The T-Cell Leukaemias / Elisabeth Grey-Davies and Claire Dearden
Cutaneous T-Cell Lymphomas / Farah Rukhsana Abdulla, Madeleine Duvic and Youn H. Kim
T-Cell Malignancies in Children and Adolescents: State of the Clinical and Biological Science / Nader Kim El-Mallawany, Pieter Van Vlierberghe, Adolfo A. Ferrando, Megan S. Lim and Mitchell S. Cairo
Approaches for First-Line Therapy of Peripheral T-Cell Lymphoma / David Sibon, Christian Gisselbrecht and Francine Foss
Autologous and Allogeneic Stem Cell Transplantation for T-Cell Lymphomas / José Rodríguez and Paolo Corradini
Monoclonal Antibodies (mAb) in the Therapy of T-Cell Lymphomas / Lapo Alinari, Pierluigi Porcu and Bertrand Coiffier
Nucleoside Analogs in the Therapy of T-Cell Malignancies / Varsha Gandhi and Pier Luigi Zinzani
Current Epigenetic Therapy for T-Cell Lymphoma / Michael Dickinson, Chan Cheah and H. Miles Prince
Novel Therapies for T-cell Lymphomas / Christiane Querfeld and Steven T. Rosen
Immunotherapy for Cutaneous T-Cell Lymphoma / Badri Modi, Francine Foss, Richard L. Edelson and Michael Girardi
Syndromes and Clinical Management Issues Associated with T-Cell Lymphomas / Merry Jennifer Markham and Nam H. Dang.