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  • Book
    volume editors, Alexa B. Kimball, M. Dennis Linder.
    Contents:
    Life span and life course approaches to dermatological disease / Ryff, C.D.
    Key concepts in the life course approach in medicine : allostatic load and cumulative life course impairment / Offidani, E.; Tomba, E.; Linder, M.D.
    Mathematical modeling in life course research / Barban, N.; Linder, M.D.
    Life course impairment and quality of life over time / Sampogna, F.
    Concept of major life-changing decisions in life course research / Bhatti, Z.U.; Salek, S.; Finlay, A.Y.
    Setting up a life course questionnaire / Sampogna, F.
    Cumulative life course impairment in chronic wounds / Augustin, M.
    Cumulative life course impairment : evidence for psoriasis / Mattei, P.L.; Corey, K.C.; Kimball, A.B.
    Cumulative life impairment by epidermolysis bullosa / Fine, J.-D.
    Cumulative life course impairment in vitiligo / Krüger, C.; Schallreuter, K.U.
    Cumulative life course impairment in melanoma and nonmelanoma skin cancer / Piaserico, S.
    Cumulative life course impairment : identifying patients at risk / Augustin, M.
    Cumulative life course impairment in dermatological diseases other than psoriasis : an overview / Ibler, K.S.; Jemec, G.B.E.
    Cumulative life course impairment across cultures and medical systems / Lima, X.T.
    Patients' narratives / Foulkes, A.C.; Warren, R.B.
    Digital Access Karger 2013
  • Article
    Duclos H, Galanaud P, Devinsky O, Maillot MC, Dormont J.
    Eur J Immunol. 1977 Oct;7(10):679-84.
    We have studied the effect of cyclophosphamide (CY) administration on the subsequent in vitro antibody response in the mouse. Treatment with a low dose (20 mg/kg) of CY four days before culture results in an increased IgM response to the T-independent antigen trinitrophenylated polyacrylamide (TNP-PAA), without affecting the background response of unstimulated cultures. This suggests that CY treatment eliminates a short-lived suppressor cell, involved in the regulation of the in vitro B cell response. In contrast, the same regimen decreases the ability of nude mouse spleen cells to respond to TNP-PAA, showing that the target of CY-enhancing effect is a mature T cell. The increased response observed in conventional mice should be the result of a balance between the direct suppressive effect of CY on B cells and the elimination of a suppresor T cell, the latter phenomenon being of predominant significance in our conditions. The target of CY-enhancing effect is nonadherent to plastic, but adherent to Sephadex G-10 columns.
    Digital Access Access Options