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  Endothelin in renal physiology and disease

  volume editors, Matthias Barton, Donald E. Kohan.

  Digital Access Karger 2011
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• Article

  Nuclear RNA content and synthesis in anterior pituitary in intact, castrated and androgen sterilized rats.

  Biró J, Endröczi E.

  Endocrinol Exp. 1977 Sep;11(3):163-8.

  The content and uridine incorporation into nuclear RNA of anterior pituitary gland was studied in vitro in intact, castrated and neonatally testosterone treated rats of both sexes. In female rats a higher RNA content and a lower uridine incorporation rate could be observed than in males. The castration resulted in a marked increase of RNA content and uridine incorporation in male rats. Ovariectomy was followed by a decrease of RNA content which was accompanied by an increase of incorporation rate. Estradiol administration produced a biphasic change of RNA content and uridine incorporation in ovariectomized rats. From these findings a repressive action of estrogens on the nuclear RNA synthesis may be suggested. Neonatal testosterone treatment resulted in alterations of RNA synthesis which could be observed in both sexes.

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