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- ArticleShimoji K, Matsuki M, Shimizu H, Iwane T, Takahashi R, Maruyama M, Masuko K.Br J Anaesth. 1977 Nov;49(11):1081-6.Low-frequency (1.6-2.2 Hz) and weak-intensity electrical stimulation in the spinal extradural space produced complete to partial pain relief in a majority of patients (22 of 25) who suffered from intractable pain. Also it produced analgesia or hypoalgesia over a wide area of the body surface in 19 of the 25.