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  • Book
    Denton A. Cooley.
    Summary: Pioneering surgeon Dr. Denton Cooley performed his first human heart transplant in 1968 and astounded the world in 1969 when he was the first surgeon to successfully implant a totally artificial heart in a human being. Over the course of his career, Cooley and his associates have performed thousands of open heart operations and have been forerunners in implementing new surgical procedures. Of all his achievements, however, Cooley is most proud of the Texas Heart Institute, which he founded in 1962 with a mission to use education, research, and improved patient care to decrease the devastating effects of cardiovascular disease. In his new memoir, 100,000 Hearts, Cooley tells about his childhood in Houston and his experiences as a basketball scholarship recipient at the University of Texas. After medical school at the University of Texas Medical Branch in Galveston and Johns Hopkins, Cooley served in the Army Medical Corps. While at Johns Hopkins, Cooley assisted in a groundbreaking operation to correct an infant's congenital heart defect, which inspired him to specialize in heart surgery. Cooley's detailed descriptions of what it was like to be in the operating room at crucial points in medical history offer a fascinating perspective on how far medical science has progressed in just a few decades. Dr. Denton Cooley and the Texas Heart Institute are responsible for much of that progress.

    Contents:
    My roots
    Boyhood friends and activities
    "This, my friend, is the UT"
    Becoming a doctor
    The dawn of heart surgery
    Army doctor
    Residency at Hopkins
    A year at the Brompton
    Pioneering cardiovascular surgery
    Opening up the heart
    An institute for the heart
    Transplanting hearts
    The total artificial heart
    The "Cooley Hilton" and beyond
    On being a surgeon
    Private life
    Reconciliation with Mike
    Summing up
    Appendic A : Glossary
    Appendix B : Personal contributions to cardiovascular surgery
    Appendix C : Surgical inventions and products
    Appendix D : Selected publications
    Appendix E : Denton A. Cooley Cardiovascular Surgical Society
    Appendix F : Curriculum Vitae
    Index.
    Print Access Request
    Location
    Version
    Call Number
    Items
    Books: General Collection (Downstairs)
    2012
    R154.C566 A3 2012
    1
  • Article
    Azuma K, Azuma M, Sickel W.
    J Physiol. 1977 Oct;271(3):747-59.
    1. Bleaching/regeneration cycles were performed in perfused frog retina while the optical transmittance at suitable wave-lengths was measured continously. Rhodopsin was identified from its spectral absorbance, its photosensitivity and from the kinetics of its regeneration. 2. In the absence of the pigment epithelium regeneration was complete when not more than 2-5% of the rhodopsin initially present had been bleached. However, the cycles could be repeated to a total of regenerated rhodopsin exceeding that explicable on the utilization of stored chromophores. The rate of regeneration was fast, with 0-12 min-1 rate constant, following first order reaction kinetics. Under these conditions the cycle does not seem to involve stages beyond metarhodopsin II. With the moderate bleaching intensities used, half-time 53 min, the Bunsen-Roscoe law was obeyed up to 15 min, indicating a capacity for the photoproducts to be accomondated in situ for subsequent regeneration. 3. It is concluded that only substantial bleaches, which exceed that capacity, result in hydrolysed chromophores. These surplus chromophores become esterified and are temporarily taken up by the pigment epithelium to be re-entered into the visual cycle as fast as they can be processed by the regenerative machinery of the rod outer segments.
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