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  Clinical gynecologic oncology. 8th ed.

  [edited by] Philip J. Di Saia, William T. Creasman ; associate editors, Robert S. Mannel, D. Scott McMeekin, David G. Mutch.

  Contents:
  Preinvasive disease of the cervix / William T. Creasman
  Preinvasive disease of the vagina and vulva and related disorders / Joan L. Walker and Cara A. Mathews
  Invasive cervical cancer / Krishnansu S. Tewari and Bradley J. Monk
  Endometrial hyperplasia, estrogen therapy, and the prevention of endometrial cancer / Lisa M. Landrum, Rosemary E. Zuna, and Joan L. Walker
  Adenocarcinoma of the uterine corpus / William T. Creasman and David Scott Miller
  Sarcoma of the uterus / D. Scott McMeekin
  Gestational trophoblastic disease / Emily M. Ko and John T. Soper
  Invasive cancer of the vulva / Jeanne M. Schilder and Frederick B. Stehman
  Invasive cancer of the vagina / Brian M. Slomovitz and Robert L. Coleman
  The adnexal mass / D. Scott McMeekin, Robert Mannel, and Philip J. Disaia
  Epithelial ovarian cancer / Eric L. Eisenhauer, Ritu Salani, and Larry J. Copeland
  Germ cell, stromal, and other ovarian tumors / Michael A. Bidus, John C. Elkas, and G. Scott Rose
  Fallopian tube cancer / Michael A. Bidus, G. Larry Maxwell, and G. Scott Rose
  Breast diseases / Mary L. Gemignani
  Cancer in pregnancy / Krishnansu S. Tewari
  Complications of disease and therapy / Daniel L. Clarke-Pearson
  Basic principles of chemotherapy / Christina S. Chu and Stephen C. Rubin
  Targeted therapy and molecular genetics / Shannon N. Westin, Anil K. Sood, and Robert L. Coleman
  Genes and cancer : genetic counseling and clinical management / David G. Mutch and Philip J. DiSaia
  Palliative care and quality of life / Dana M Chase ... [et al.]
  Role of minimally invasive surgery in gynecologic malignancies / Jeffrey M. Fowler, David E. Cohn, and Robert S. Mannel
  Epidemiology of commonly used statistical terms and analysis of clinical studies / Wendy R. Brewster
  Basic principles in gynecologic radiotherapy / Catheryn M. Yashar.

  Digital Access ScienceDirect 2012
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• Article

  Concentrations of flurbiprofen in serum and synovial fluid from patients with active rheumatoid disease: some preliminary observations.

  Chalmers TM, Glass RC, Risdall PC.

  Curr Med Res Opin. 1977;5(1):17-20.

  In 3 patients with active rheumatoid disease, concentrations of flurbiprofen of approximately 2 microgram per ml were achieved in synovial fluid 3 hours after a single oral dose of flurbiprofen (100 mg). The highest concentrations were seen between 3 and 9 hours after administration of the dose. The concentration of flurbiprofen in synovial fluid seemed to fall more slowly than in the circulation, but more extensive data would be needed to confirm this. In all 3 patients the drug was absorbed rapidly into the circulation, the highest serum concentrations of 7 microgram to 9 microgram per ml being seen in the first blood sample withdrawn 1.5 hours after administration of the dose. Serum concentrations fell with a mean apparent half-life of approximately 3 hours.

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  PubMed