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- BookDamiaan Denys, Matthijs Feenstra, Rick Schuurman, editors.Contents:
Basic Principles of Deep Brain Stimulation / F. L. H. Gielen and G. C. Molnar
Neural Circuits Affected by Deep Brain Stimulation for the Treatment of Psychiatric Disorders / Suzanne N. Haber and Benjamin D. Greenberg
Mechanisms of Action of Deep Brain Stimulation for the Treatment of Psychiatric Disorders / J. Luis Lujan and Cameron C. McIntyre
Deep Brain Stimulation in the Ventral Capsule/Ventral Striatum for the Treatment of Obsessive-Compulsive Disorder: Role of the Bed Nucleus of the Stria Terminalis / Loes Gabriëls and Bart Nuttin
Deep Brain Stimulation in Obsessive-Compulsive Disorder Targeted at the Nucleus Accumbens / Pelle P. de Koning, Pepijn van den Munckhof, Martijn Figee, Rick Schuurman and Damiaan Denys
What is the Role of the Subthalamic Nucleus in Obsessive-Compulsive Disorder? Elements and Insights from Deep Brain Stimulation Studies / William I. A. Haynes and Luc Mallet
Obsessive-Compulsive Disorders in Animals / Christine Winter
Subcallosal Cingulate Cortex Deep Brain Stimulation for the Treatment of Refractory Mood Disorders: Evidence and Challenges / Peter Giacobbe, Nir Lipsman and Andres M. Lozano
Deep Brain Stimulation of the Human Reward System as a Putative Treatment for Refractory Major Depression / T. E. Schlaepfer, V. A. Coenen and B. H. Bewernick
Depression in Humans: The Ventral Capsule/Ventral Striatum / Mayur Pandya, Andre Machado and Donald Malone
Deep Brain Stimulation in Animal Models of Depression / Brian W. Scott, José N. Nobrega and Clement Hamani
Deep Brain Stimulation in Tourette Syndrome / L. Ackermans, I. Neuner, J. Kuhn and V. Visser-Vandewalle
Surgical Treatments for Drug Addictions in Humans / Bomin Sun and Wei Liu
Manipulating Addictive Behaviour in Animal Models / Rolinka M. C. Schippers, Tommy Pattij and Taco J. De Vries
Neuropsychiatric Side Effects of Deep Brain Stimulation in Parkinson's Disease / Christine Daniels and Jens Volkmann
Psychiatric Aspects of Parkinson's Disease in Animal Models of Deep Brain Stimulation of the Subthalamic Nucleus / S. K. H. Tan, H. Hartung, V. Visser-Vandewalle, T. Sharp and Y. Temel
Scientific Recordings in Deep Brain Stimulation / Michael X. Cohen
Neurotransmitter Release During Deep Brain Stimulation / Osama A. Abulseoud, Emily J. Knight and Kendall H. Lee
The Potential Role of Nonneuronal Cells in the Deep Brain Stimulation Mechanism: What Are Glia? What Are Their Functions? Could They Be Players in Deep Brain Stimulation? / Vinata Vedam-Mai, Michael S. Okun and Elly M. Hol
Animal Studies in Deep Brain Stimulation Research / Matthijs G. P. Feenstra and Damiaan Denys
Neuroimaging Deep Brain Stimulation in Psychiatric Disorders / Martijn Figee, Pepijn van den Munckhof, Rick Schuurman and Damiaan Denys
Optogenetic Strategies for the Treatment of Neuropsychiatric Disorders: Circuit-Function Analysis and Clinical Implications / Daniel L. Albaugh and Garret D. Stuber
Next-Generation Electrodes for Steering Brain Stimulation / H. C. F. Martens, M. M. J. Decré and E. Toader
Future Applications: Nanotechniques / Russell J. Andrews, Jessica E. Koehne and Meyya Meyyappan
Ethical Guidance for the Use of Deep Brain Stimulation in Psychiatric Trials and Emerging Uses: Review and Reflections / Emily Bell and Eric Racine
History of "Psychiatric" Deep Brain Stimulation: A Critical Appraisal / Marwan I. Hariz.Digital Access Springer 2012 - ArticleKadish AS, Bases RE, Feingold J, Spiro J, Ghossein NA, Bloom BR.J Natl Cancer Inst. 1977 Nov;59(5):1369-74.The virus plaque assay (VPA), an assay capable of enumerating mitogen- or antigen-sensitive T-lymphocytes in a given cell population, was applied to the study of mitogen responses of peripheral blood leukocytes (PBL) in 50 patients with localized, solid cancers and in 29 normal controls. Concanavalin A (Con A)-responsive virus plaque-forming cells (V-PFC) were significantly reduced in the patients as compared with those of the controls. PBL from 20 of the patients but only 2 of the controls failed to show significant increments in V-PFC over background when cultured in the presence of Con A. This deficient response was also present in the patients when phytohemagglutinin was used as the mitogenic agent. Mitogen-stimulated uptake of [3H]thymidine (TdR) in parallel cultures failed to show a statistically significant difference between the patients and the controls, though some patients showed diminished stimulation in this assay. The VPA thus appeared to detect a defect of T-lymphocyte function not found in the [3H]TdR incorporation assay.