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  • Book
    by Giovanni Boniolo.
    Contents:
    Deliberation and Democracy
    Plato Was Not So Far Wrong: Recalling Athenian Democracy
    A Reappraisal of the Medieval Approach Will Lead to Excellent Deliberators
    Beware of Those Who Think They Possess the Truth!
    Let Us Learn How to Deliberate before Deliberating!
    Between Ethics and Biomedicine.
    Digital Access Springer 2012
  • Article
    Lancranjan I, Wirz-Justice A, Pühringer W, Del Pozo E.
    J Clin Endocrinol Metab. 1977 Sep;45(3):588-93.
    The effect of a new soluble ester of 1-5 hydroxytryptophan (1-5 HTP, Ro 3-5940, 200 mg infusion) on prolactin (PRL) and growth hormone (GH) release was tested in 11 young, healthy subjects (6 men, 5 women). To minimize side-effects, peripheral decarboxylase inhibition was achieved with benserazide (Ro 4-4602.) PRL increased significantly (P less than 0.01) after benserazide alone in all subjects. A further significant increase (P less than 0.01) of PRL plasma levels occurred only in women up to 90 min after the infusion of 1-5 HTP was discontinued. Benserazide administration had no effect of basal GH levels, but a significant increase of GH release (P less than 0.01) was noticed 30-120 min after the end of 1-5 HTP infusion in both men and women. The mean peak value of GH plasma levels after 1-5 HTP administration was 32.0 +/- 8.8 ng/ml. It was postulated that benserazide penetrated at the level of the pituitary, decreasing the synthesis of dopamine and consequently reducing its known inhibitory effect on PRL release. The PRL increase (statistically significant only in women), as well as the release of GH after 1-5 HTP infusion, was considered as further evidence for stimulatory serotoninergic control of both PRL and GH secretion.
    Digital Access Access Options