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- BookLue, Tom F.; McAninch, Jack W.; Smith, Donald R.; Tanagho, Emil A.Digital AccessProviderVersionAccessMedicineAccessSurgeryAccessSurgery
- ArticlePrimi D, Smith CI, Hammarström L, Lundquist PG, Möller G.Clin Exp Immunol. 1977 Aug;29(2):316-9.Supernatants from human tonsil cells cultured in the presence of the PBAs, LPS and F (ab)2 monomers of rabbit anti-human beta2-microglobulin were found to have a complement-dependent cytotoxic activity to tonsil cells of the same donors. A direct toxic effect of the PBAs on the target cells was excluded by controls. Therefore the most likely explanation for this finding is that human lymphocytes contain a subpopulation of self-reactive B cells which can be triggered by PBAs to release antibodies to self-antigens. The implications of this finding for the understanding of infections accompanied by auto-immune phenomena are discussed.