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  • Book
    Tony Harris, editor.
    Contents:
    Introduction to adherens junctions: from molecular mechanisms to tissue development and disease
    How AJs evolved
    Evolution of the cadherin-catenin complex
    How cadherins and catenins interact to assemble AJs
    Three-dimensional structure of the cadherin-catenin complex
    Biophysics of cadherin adhesion
    Adherens junction assembly
    How AJs interface with other cellular machinery
    Cytoskeleton and classical cadherin adhesions
    Immunoglobulin superfamily receptors and adherens junctions
    Signaling from the adherens junction
    Adherens junction turnover: regulating adhesion through cadherin endocytosis, degradation, and recycling
    How AJs affect cell behaviour and multicellular development
    Adherens junctions during cell migration
    Adherens junctions and cadherins in Drosophilia development
    Adherens junctions in C. elegans embryonic morphogenesis
    Cadherin function during xenopus gastrulation
    Adherens junctions in mammalian development, homeostasis and disease: lessons from mice
    How AJs affect tissue homeostasis and disease
    Adherens junctions and stem cells
    Adherens junctions and cancer
    Adherens junctions and pathogen entry.
    Digital Access Springer 2012
  • Article
    Nelson JA, Harris BA, Decker WJ, Farquhar D.
    Cancer Res. 1977 Nov;37(11):3970-3.
    Methotrexate in human plasma at a concentration as low as 0.01 microgram/ml can be assayed with the use of high-pressure-liquid chromatography and a fluorescence detection system. Methotrexate is oxidized stoichiometrically to 2,4-diaminopteridine-6-carboxylic acid, a fluorescent product that is separable from other fluorescent materials in plasma with the use of an octadecylsilane (reversed phase) column. The detector response is linear over the range of 0.01 to 10 microgram/ml. Neither folic acid nor citrovorum factor interferes with the analysis. N-((4-([2,4-Dihydroxy-6-pteridyl)methyl]-amino)benzoyl))glutamic acid may be used as an internal standard, since it can be extracted from plasma and oxidized like methotrexate. The procedure is rapid (about 30 min) and should be a useful method for monitoring methotrexate plasma concentrations.
    Digital Access Access Options