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  • Book
    Clive G. Wilson, Patrick J. Crowley, editors.
    Contents:
    A short history of controlled drug release
    The organization of the gut and oral absorption of drugs: anatomical, biological and physiological considerations in oral formulation development
    Controlling drug release in oral product development programs: an industrial perspective
    Animal model systems suitable for controlled release modeling
    In Vitro testing of controlled release dosage forms during development and manufacture
    Oral controlled delivery mechanisms and technologies
    Drug-polymer matrices for extended release
    Ion-exchange approaches to controlling drug release
    Pulsatile delivery for controlling drug release
    Ordered mesoporous silica for the delivery of poorly soluble drugs
    Geometric release systems: principles, release mechanisms, kinetics, polymer science, and release-modifying material
    Extrudable technologies for controlling drug release
    Coated multiparticles for controlling drug release
    Capsules as a delivery system for modified-release products
    Lipids in oral controlled release drug delivery
    Biccal drug delivery
    Controlling release by gastroretention
    Drug delivery to the colon.
    Digital Access Springer 2011
  • Article
    Kemple K, Bluestone R.
    Med Clin North Am. 1977 Mar;61(2):331-45.
    Histocompatibility typing has assumed an increasingly important role as a clinical and research tool in rheumatic diseases. The HLA antigens which are serologically defined (A and B series) are being used most extensively for clinical work, but the role of other immunologic determinants in the HLA complex is being evaluated. These include D-locus (MLC) determinants, several complement components, and immune response genes which have been well characterized in the mouse, but not in man. The products of the major histocompatibility complex are inherited in a simple Mendelian fashion as a series of co-dominant alleles. Large population studies have characterized the frequencies of various alleles, and family studies have allowed tentative mapping of the various loci within the complex on the sixth chromosome in man. A number of diseases which are considered to be autoimmune in nature are now known to be associated with specific HLA antigens. Of these disease associations, the strongest and best studied are the seronegative spondyloarthropathies which are highly associated with the B27 antigen. Included in this group are ankylosing spondylitis, Reiter's syndrome, psoriatic arthropathy, colitic arthropathy, Yersinia arthritis and a small group of juvenile rheumatoid arthritis patients with features of ankylosing spondylitis. The clinical application of tissue typing or B27 testing is most helpful in regard to difficult diagnostic problems in patients with early or atypical seronegative spondyloarthropathy. Its value as an indicator of prognosis, and its value in counselling family members is not well established. There are many interesting hypotheses regarding pathogenetic mechanisms of these rheumatic diseases based on susceptibility factors related to the major histocompatibility complex. An abnormal immune response gene within the complex is probably a key feature of the mechanism, but the exact details are little more than speculative at this point.
    Digital Access Access Options