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- BookAlison L. Allan, editor.Contents:
Cancer stem cells : historical perspectives and lessons from leukemia / Christopher R. Cogle
Cancer stem cells in breast cancer / Jenny E. Chu and Alison L. Allan
Cancer stem cells in brain cancer / Xin Wang, Chitra Venugopal, and Sheila K. Singh
Cancer stem cells in colorectal cancer / Mauro Biffoni, Eros Fabrizi, and Lucia Ricci-Vitiani
Cancer stem cells in pancreatic cancer / Jorge Dorado, Alicia G. Serrano, and Christopher Heeschen
Cancer stem cells in prostate cancer / Paula Kroon ... [et al.]
Cancer stem cells in melanoma / Ping Jin ... [et al.]
Cancer stem cells in lung cancer / Jun Shen and Feng Jiang
Cancer stem cells in ovarian cancer / Fang Fang ... [et al.]
Cancer stem cells in hepatocellular cancer / Russell C. Langan and Itzhak Avital
Cancer stem cells in head and neck cancer / Mark E.P. Prince and Samantha J. Davis
Relationship between regulatory pathways in pluripotent stem cells and human tumors / Olga Gaidarenko and Yang Xu
Influence of the embryonic microenvironment on tumor progression / Daniela Quail ... [et al.]
The epithelial-to-mesenchymal transition and cancer stem cells / Jonas Fuxe
Application of stem cell assays for the characterization of cancer stem cells / Pamela M. Willan and Gillian Farnie
Zebrafish as a model to study stem cells in development, disease, and cancer / Viviana Anelli, Cristina Santoriello, and Marina C. Mione
Imaging cancer stem cells / Paula Foster
Mouse models for studying normal and cancer stem cells / David A. Hess
Cancer stem cells and disease prognosis / Zeshaan A. Rasheed, Jeanne Kowalski, and William H. Matsui
Mechanisms of radioresistance in cancer stem cells / Cleo Y-F Lee and Maximilian Diehn
The role of ABC transporters in cancer stem cell drug resistance / Vera S. Donnenberg, Ludovic Zimmerlin, and Albert D. Donnenberg
Resistance to endocrine therapy in breast cancer : are breast cancer stem cells implicated? / Ciara S. O'Brien ... [et al.]
Future directions : cancer stem cells as therapeutic targets / Alysha K. Croker and Alison L. Allan
Final thoughts : complexity and controversy surrounding the "cancer stem cell" paradigm / Craig Gedye, Richard P. Hill, and Laurie Ailles.Digital Access Springer 2011 - ArticleSchill WB.Fortschr Med. 1977 Mar 24;95(12):790-2.The trypsin-like enzyme acrosin has a key function in the fertilization process enabling penetration of the zona pellucida of the ovum by the spermatozoa. Under experimental conditions acrosin inhibitors are able to prevent fertilization. In the male genital tract high amounts of low molecular weight acid-stable proteinase inhibitors are found having mainly protective functions, but may play also a significant role in the process of capacitation. Aside from biochemical and physiological investigations the presented studies are a contribution towards the clinical applicability of the acrosin-inhibitor system with special respect to its diagnostic and prognostic value for andrology. In addition, inhibition of acrosin may be an approach for an effective contraceptive method.