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- BookAnders A. F. Sima, editor.Contents:
1. C-Peptide and Insulin: A Happy Marriage / Donald F. Steiner
2. Peptide Interactions of Proinsulin C-Peptide / Charlotte Nerelius, Emma Lindahl, Michael Landreh, and Hans Jörnvall
3. The Effect of Combined C-Peptide and Zinc on Cellular Function / Dana M. Spence
4. C-Peptide Signaling in the Kidney and Protection from Diabetic Nephropathy / Nigel J. Brunskill
5. Role of C-Peptide in the Regulation of Microvascular Blood Flow / Thomas Forst, Matthias M. Weber, Thomas Kunt, and Andreas Pfützner
6. Is NO-eNOS a Target for C-Peptide Action and Its Protective Effects on Diabetic Nephropathy? / Kazuhiro Kimura and Akihiro Kamikawa
7. Renoprotective Effects of C-Peptide on Type 1 Diabetes / Lina Nordquist, Åsa Kallas, Sara Stridh, Fredrik Palm, and John Wahren
8. The Mechanisms Underlying the Effects of C-Peptideon Type 1 Diabetic Neuropathy / Hideki Kamiya, Wei-Xian Zhang, and Anders A.F. Sima
9. C-Peptide and Type 1 Diabetic Encephalopathy / Anders A.F. Sima and Wei-Xian Zhang
10. C-Peptide: A New Moleculewith Anti-Inflammatory Properties / Jaime Haidet, Vincenza Cifarelli, Xuehui Geng, Massimo Trucco, and Patrizia Luppi
11. C-Peptide: Connecting Diabetes with Macrovascular Complications / Karen E. Porter and Romana S. Mughal
12. C-Peptide and Diabetic Neuropathy in Patients with Type 1 Diabetes / Karin Ekberg and John Wahren
13. Proatherogenic Effects of C-Peptide / Daniel Walcher and Nikolaus Marx
14. Conclusions and Future Outlook / Anders A.F. Sima.Digital Access Springer 2012 - ArticleEkstedt RD, Waterfield JD, Nespoli L, Möller G.Scand J Immunol. 1977;6(3):247-53.The addition of a small proportion (10%) of in vivo concanavalin-A (Con-A)-activated spleen cells to normal spleen cell cultures suppressed the primary immune response to sheep erythrocytes (SRBC) but had no effect on the thymus-independent primary immune response to 3,5-dinitro-4-hydroxy-phenacetyl-conjugated lipopolysaccharide. When Con-A-activated cells were added after 24 h, there was no suppression of the anti-SRBC response but rather an enhanced response when few cells were admixed. Con-A-activated cells did not influence activation of normal cells by polyclonal T- and B-cell activators. It is concluded that Con-A-induced suppressor cells do not act on B cells but rather on helper cells (T cells or macrophages) at a very early stage of the immune response to thymus-dependent antigens.