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  • Book
    Anil Chandraker, Mohamed H. Sayegh, Ajay K. Singh, editors.
    Contents:
    1. Transplantation Immunobiology / Melissa Yeung
    2. Basic Histocompatibility Testing Methods / Kathryn J. Tinckam
    3. Medical Evaluation of the Living Kidney Donor / Julie Lin
    4. Evaluation of Renal Transplant Candidates / Martina M. McGrath and Mario F. Rubin
    5. Surgical Management of the Renal Transplant Recipient / Sayeed K. Malek and Stefan G. Tullius
    6. Overview of Immunosuppressive Therapies in Renal Transplantation / Steven Gabardi and Eric M. Tichy
    7. Allograft Dysfunction: Diagnosis and Management / Colm C. Magee
    8. Approach to Medical Complications After Kidney Transplantation / John Vella
    9. Infectious Complications in Renal Transplant Recipients / Erik R. Dubberke and Daniel C. Brennan
    10. Recurrent and De Novo Glomerulonephritis After Kidney Transplantation / Austin Hunt and Mark D. Denton.
    Digital Access Springer 2012
  • Article
    Griggs TR, Potter JS, McClanahan SB, Webster WP, Brinkhous KM.
    Proc Natl Acad Sci U S A. 1977 Feb;74(2):759-63.
    The physiologic activities concerned with hemostasis and associated with the Factor VIII macromolecular complex were investigated in swine with von Willebrand's disease after infusion of cryoprecipitate, a lyophilized Factor VIII concentrate, or porcine serum. Immediately after each infusion the various activities antihemophilic factor, von Willebrand platelet aggregating factor, and Factor VIII-related antigen, were elevated in approximate proportion to dose and the bleeding time was shortened.There was a late secondary rise in antihemophilic factor. During the period after infusion, there was a differential fall-off of the various activities, with the bleeding time effect lost first, followed by the von Willebrand platelet aggregating factor and then by the Factor VIII-related antigen. The plasma from swine with von Willebrand's disease late after infusion contained high levels of antihemophilic factor without other detectable activities of the complex. Antihemophilic factor, free of the other components, obtained from plasma from swine with von Willebrand's disease either before or late after infusion eluted from agarose gel columns both as high and lower molecular weight material, unlike normal antihemophilic factor, which had a high molecular weight. In contrast, on ultracentrifugation the antihemophilic factor in these plasma sedimented slowly, even though chromatographically the plasmas contained both high and low molecular weight factor. All of the Factor VIII complex activities in normal porcine plasma sedimented rapidly. These studies demonstrate the heterogeneity of the Factor VIII complex and the apparent dependence of its chromatographic and sedimentation behavior on the functional activities associated with the complex.
    Digital Access Access Options