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- ArticleBell R, Sullivan JR, Moon WJ, Hurley TH.Med J Aust. 1977 Feb 19;1(8):247-9.Eighty-six adults with malignant disease were given high doses of methotrexate with folinic acid rescue, with acceptable toxicity. Protocal violations in two cases led to death. The results of therapy in some diagnostic groups are encouraging.