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  • Book
    Mark L. Goldstein, Stephen Morewitz.
    Contents:
    Epidemiology, Health Services Utilization, and Costs
    Chromosomal Abnormalities
    Autism
    Cerebral Palsy
    Attention-Deficit Hyperactivity Disorder
    Sensory Integration Dysfunction
    Conduct Disorder and Oppositional Defiant Disorder
    Depressive Disorders in Children and Adolescents
    Eating Disorders
    Childhood and Adolescent Obesity
    Diabetes Mellitus
    Juvenile Arthritis
    Infants, Children, and Adolescents Affected by HIV/AIDS.
    Digital Access Springer 2011
  • Article
    Cochrane AM, Moussouros A, Portmann B, McFarlane IG, Thomson AD, Eddleston, Williams R.
    Gastroenterology. 1977 May;72(5 Pt 1):918-23.
    To determine whether an autoimmune reaction to liver-specific proteins occurs in alcoholic liver disease, the cytotoxic effect of lymphocytes on isolated hepatocytes was determined in 27 alcoholic patients. Cytotoxicity was demonstrated in 15 of 17 patients with a histological diagnosis of alcoholic hepatitis, but in none of 10 with other forms of alcoholic liver disease. The ability of a liver-specific membrane lipoprotein to block the reaction suggests that sensitization to this antigen is responsible for the cytotoxicity. The demonstration of cytotoxicity using T cell-depleted, but not B and K cell-depleted, lymphocytes suggests an antibody-dependent cell-mediated reaction. There was a close correlation between cytotoxicity and the presence of alcoholic hyalin, liver cell necrosis, and piecemeal necrosis, but not with other histological features, immunoglobulines, autoantibodies, or standard liver function tests. The persistence of this autoimmune response, induced in some way by alcohol or one of its metabolites, may be important in the progression of acute alcoholic hepatitis to chronic liver disease.
    Digital Access Access Options