Bookedited by Sanjiv Sam Gambhir, Shahriar S. Yaghoubi.
Summary: "Reporter genes have been used for several decades to study regulation of gene expression in vivo. However, it was little more than a decade ago that a new class of reporter genes was developed for imaging molecular events within living subjects. By following the interactions of protein molecules, researchers can resolve the complex chemical pathways that living cells utilize. This book focuses on this group of imaging reporter genes, starting with detailed descriptions of all reporter genes from different imaging modalities, including optical, MRI, and radionuclide-based imaging. Key scientists in the field explain how to enhance reporter gene imaging utility through instrumentation and the various applications of this technology. This is the first comprehensive book on all aspects of reporter gene imaging, detailing what is known in the field and future goals for research. Investigators in biomedical sciences, physicians, and the biotechnology and pharmaceutical industries will benefit from topics covered here"--Provided by publisher.
Contents:
Types of imaging reporter genes
Fluorescent reporter proteins / Robert E. Campbell and Michael W. Davidson
Revealing biomolecular mechanisms through in vivo bioluminescence imaging / Timothy C. Doyle, Qian Wang, and Christopher H. Contag
Reporter gene imaging with PET/SPECT June-Key Chung, Joo Hyun Kang, and Keon Wook Kang
Noninvasive imaging of gene expression with magnetic resonance imaging and magnetic resonance spectroscopy / Mark D. Pagel and James P. Basilion
Enhancing reporter gene imaging techniques
Multimodality imaging of reporter gene / Pritha Ray and Sanjiv Sam Gambhir
Cell-specific imaging of reporter gene expression using a two-step transcriptional amplification strategy / Marxa L. Figueirdo ... [et al.]
Imaging instrumentations
Physics, instrumentation, and methods for imaging reporter gene expression in living subjects / Craig S. Levin
current applications of imaging reporter genes
Reporter gene imaging of cell signal transduction / Tarik F. Massoud ... [et al.]
Gene therapy and imaging of transgene expression in living subjects / Shahrihar S. Yaghoubi and Sanjiv Sam Gambhir
Imaging regulation of endogenous gene expression in living subjects / Vladimir Ponomarev
Imaging cell trafficking and immune cell activation using PET reporter genes / Evan D. Nair-Gill ... [et al.]
Imaging reporter genes and stem cells / Martin G. Rodriguez-Porcel and Sanjiv Sam Gambhir
Clinical applications of reporter gene technology / Iván Peñuelas ... [et al.].
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