BookTibor Tot, editor.
Summary: The theory of the sick lobe states that breast carcinoma is a lobar disease developing most often within a single lobe, meaning that, at an early stage, breast carcinoma occupies a limited, anatomically well-defined portion of the breast. This theory unites observed patterns from the genetic, developmental and morphological perspectives, into an overall concept. "Breast Cancer: A Lobar Disease," presents this hypothesis and its consequences. The body of evidence, pro and contra, generated in recent years will be presented in this volume. The chapters, all authored by leading experts.
Contents:
The theory of the sick lobe
Lobar anatomy of human breast and its importance for breast cancer
Breast cancer may originate in utero: the importance of the intrauterine environment for breast cancer development
Genetic alterations in normal and malignant breast tissue
The role of ductal lavage: a cautionary tale
The distribution of the earliest forms of breast carcinoma
The implications of the imaging manifestations of multifocal and diffuse breast cancers
Lobar ultrasound of the breast
The lobar distribution of the lesions in breast carcinoma: ductoscopy and surgery
Strop breast cancer now!: imagining imaging pathways towards search, destroy, cure, and watchful waiting of premetastasis breast cancer
Epilogue: the diseased breast lobe in the context of X-chromosome inactivation and differentiation waves.