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  Handbook of pediatric orthopedics. 2nd ed.

  Paul D. Sponseller.

  Contents:
  Anatomy and normal development in children
  Disorders of skeletal growth and development
  Skeletal syndromes and systemic disorders in pediatric orthopedics
  Neuromuscular disorders in pediatric orthopedics
  Pediatric trauma
  Normal values and medications
  Common procedures.

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  Books: General Collection (Downstairs)

  2011

  RD732.3.C48 S66 2011

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• Article

  Anti-androgen TSAA-291. VII. On the mechanism of anti-androgenic action of 16 beta-ethyl-17 beta-hydroxy-4-oestren-3-one (TSAA-291).

  Nakayama R, Masuoka M, Hiraga K, Miki T.

  Acta Endocrinol Suppl (Copenh). 1979;229:100-7.

  The mechanism of anti-androgenic action of a steroidal compound, TSAA-291, was summarized and discussed in reference to its drug-designing and structure-activity relationship. The target of the drug-design was to obtain a substance which is inactive in androgenic activity and is capable of antagonistically competing with androgen for the receptor. With this intention, the androgen molecule was rendered with a steric hindrance influencing upon the functional 17 beta-hydroxy group. Introduction of a bulky group at the steroidal position-13 or -16 led to anti-androgenic properties. Intense steric hindrance by introducing an enormously bulky group or complete elimination of the 17 beta-hydroxy group rather decreased the anti-androgenic activity. Of these anti-androgens thus synthesized, TSAA-291 proved to be the most active in the anti-androgen assay and also antagonistic against the uptake of [3H]testosterone by the rat ventral prostate.

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