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  • Book
    Siddhartha Mukherjee.
    Contents:
    "Of blacke cholor, without boyling"
    An impatient war
    "Will you turn me out if I can't get better?"
    Prevention is the cure
    "A distorted version of our normal selves"
    The fruits of long endeavors
    Atossa's war.
    Digital Access 2010
    Limited to 3 simultaneous users
    Print Unavailable: Checked out Recall Item
    Location
    Version
    Call Number
    Items
    Books: History - LC Classification (Downstairs)
    RC275 .M85 2010
    1
  • Article
    Pierce GB, Lewis SH, Miller GJ, Moritz E, Miller P.
    Proc Natl Acad Sci U S A. 1979 Dec;76(12):6649-51.
    A bioassay, based on tumorigenicity, has been developed to determine the mechanism whereby the blastocyst of the mouse controls malignant expression of embryonal carcinoma. The assay is based upon the incidence of tumors obtained when known numbers of cells of the 402AX strain of embryonal carcinoma are injected into strain 129 mice, compared to the incidence obtained when the same number of embryonal carcinoma cells are incorporated into Swiss-Webster blastocysts that are then injected in strain 129 animals. The results indicate that the blastocyst can regulate one embryonal carcinoma cell consistently; it may have a slight effect on three, but it cannot regulate four or five of them. The position of the embryonal carcinoma cell in the blastocyst is important. Regulation occurs if the embryonal carcinoma cell is placed in the blastocoele cavity, but enhancement of tumorigenicity is obtained if it is placed between the zona pellucida and the trophectoderm. By contrast, the blastocyst is unable to regulate a single B-16 melanoma cell placed in the blastocoele cavity, indicating a degree of specificity for the regulatory process.
    Digital Access Access Options