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  • Book
    Mental Health Gap Action Programme, World Health Organization.
    Summary: The mhGAP-IG has been developed through an intensive process of evidence review. A WHO Guideline Development Group of international experts conducted systematic reviews to develop evidence-based recommendations. The recommendations were then converted into clearly presented stepwise interventions and then circulated among a wider range of reviewers across the world to include all the diverse contributions. The mhGAP-IG is based on the mhGAP Guidelines on interventions for mental, neurological and substance use disorders (http:// www.who.int/mental_health/mhgap/evidence/en/). Both documents will be reviewed and updated in 5 years. Any revision and update before that will be made to the online version of the document.--(excerpt, p. 1).

    Contents:
    I. Introduction
    -- II. General principles of care
    -- III. Master chart
    -- IV. Modules
    1. Moderate-severe depression
    2. Psychosis
    3. Bipolar disorder
    4. Epilepsy / seizures
    5. Developmental disorders
    6. Behavioural disorders
    7. Dementia
    8. Alcohol use and alcohol use disorders
    9. Drug use and drug use disorders
    10. Self-harm / suicide
    11. Other significant emotional or medically unexplained complaints
    -- V. Advanced psychosocial interventions
    Digital Access WHO 2010
    Print Access Request
    Location
    Version
    Call Number
    Items
    Books: General Collection (Downstairs)
    c2010
    RA790.5 .M54 2010
    1
  • Article
    Papayannopoulou T, Kalmantis T, Stamatoyannopoulos G.
    Proc Natl Acad Sci U S A. 1979 Dec;76(12):6420-4.
    To investigate whether the level of maturity of human erythroid cells influences the expression of the fetal hemoglobin program, we studied the relative production of fetal (Hb F) and adult (Hb A) hemoglobins during the maturation of erythroid clones produced in vitro by adult or neonatal erythroid stem cells. In both the adult and the neonatal cell cultures, clones composed of immature erythroblasts showed a significantly higher Hb F/Hb A ratio compared to the mature clones. Culture conditions enhancing erythroid cell maturity (such as an increase in the level of erythropoietin or culture time) decreased the relative synthesis of Hb F in the maturing erythroid cells. Direct immunofluorescence studies demonstrated earlier production of Hb F compared with Hb A during maturation of adult-origin HbF-synthesizing clones. The findings show that the final expression of Hb F is influenced by the degree of maturity of the terminally differentiated cells and suggest that, in addition to regulation at the level of erythroid stem cells, there is control of Hb F expression during erythroblast maturation. The inverse relationship between Hb F expression and level of cell maturity suggests that a regulatory mechanism operating throughout the process of erythroid stem cell differentiation/erythroblast maturation decreases the potential of Hb F expression as the development of the erythroid cell advances.
    Digital Access Access Options