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- ArticleKoelle GB, Rickard KK, Ruch GA.Proc Natl Acad Sci U S A. 1979 Nov;76(11):6012-6.When homogenates of cat or rat superior cervical ganglia in Krebs-Ringer solution were incubated at 37 degrees C, the ensuing decrease in acetylcholinesterase (acetylcholine acylhydrolase, EC 3.1.1.7) activity was increased significantly by prior administration in vivo of tetramonoisopropylpyrophosphotetramide at doses that produced selective alkylphosphorylation of butyrylcholinesterase or propionylcholinesterase. These findings are consistent with the proposal that the latter enzymes are posttranscriptional precursors of acetylcholinesterase. Results of similar studies with homogenates of ganglia in water or in M NaCl/1% Triton X-100 were inconclusive, as were those of heat-inactivation studies and immunoprecipitation of the enzymes.
- Bookeditors-in-chief, George F. Koob, Michel Le Moal, Richard F. Thompson.Contents:
Subject Classification:
Addiction
Animal Models of Behavior
Behavioral Genetics
Brain Aging
Brain Structure and Function
Cognitive Neuroscience
Disease and Dysfunction
Developmental Biology
Emotion and Emotional Behavior
Ethology and Neuroethology
Evolution and Comparative Biology
History
Language and Communication
Learning and Memory
Molecular Neurobiology
Motivation and Reward
Motor Systems and Motor Control
Neuroplasticity
Psychoneuroendocrinology
Reproductive , Parental and Sexual behavior
Sensation and Perception
Sleeping, Waking and Arousal
Social Behavior/Cognition
Stress.Digital Access ScienceDirect 2010